| Identification | Back Directory | [Name]
BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT | [CAS]
71730-64-8 | [Synonyms]
THR-SER-LYS
H-Thr-Ser-Lys-OH
thr-ser-lys acetate
threonyl-seryl-lysine
Thr-Ser-Lys acetate salt
H-THR-SER-LYS-OH ACETATE SALT
threonine-serine-lysine acetate
THR-SER-LYS (THR-SER-LYS ACETATE)
L-Lysine, N2-(N-L-threonyl-L-seryl)-
BOVINE PINEAL ANTIREPRODUCTIVE PEPTIDE
BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE
BOVINE PINEAL ANTIREPRODUCTIVE TRIPEPTIDE ACETATE SALT
Bovine Pineal Antireproductive Tripeptide acetate salt H-Thr-Ser-Lys-OH acetate salt
(2S)-6-amino-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]hexanoic acid | [Molecular Formula]
C13H26N4O6 | [MDL Number]
MFCD00057639 | [MOL File]
71730-64-8.mol | [Molecular Weight]
334.37 |
| Hazard Information | Back Directory | [Uses]
Threonyl-seryl-lysine, a bovine pineal antireproductive tripeptide, has antigonadotropic activity. Threonyl-seryl-lysine binds to luteinizing hormone-releasing hormone (LHRH) at a site comprised of LHRH 2-5[1][3]. | [Definition]
ChEBI: Thr-Ser-Lys is an oligopeptide. | [in vivo]
Threonyl-seryl-lysine (175 ng, i.p.) reduces the 5-day compensatory ovarian hypertrophy in unilaterally ovariectomized (UO) mice[1].
Threonyl-seryl-lysine (1 or 5 μg, i.p.) delays vaginal opening time in female Charles River CD rats[2].
Threonyl-seryl-lysine (1 and 10 μg, s.c., for 15 days) increases the weight of ovaries and of adrenals in mice[4].
| Animal Model: | Unilaterally ovariectomized (UO) mice | | Dosage: | 175 ng | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Reduced serum follicle stimulating hormone (FSH) in UO mice. |
| [References]
[1] Orts RJ, et al. Inhibitory properties of a bovine pineal tripeptide, threonylseryllysine, on serum follicle-stimulating hormone. Neuroendocrinology. 1980 Aug;31(2):92-5. DOI:10.1159/000123056
[2] Benson B. Bovine pineal tripeptide threonylseryllysine retards puberty in female rats. J Pineal Res. 1989;6(4):351-7. DOI:10.1111/j.1600-079x.1989.tb00431.x
[3] Root-Bernstein RS, et al. Bovine pineal antireproductive tripeptide binds to luteinizing hormone-releasing hormone: a model for peptide modulation by sequence specific peptide interactions? Brain Res Bull. 1986 Oct;17(4):519-28. DOI:10.1016/0361-9230(86)90219-4
[4] Vaughan M K, et al. Influence of Thr-Ser-Lys (TSL), a recently isolated pineal peptide, on ovarian and uterine weights and estrous cycles in mice, hamsters and rats. Pineal function (Mathews CD, Seamark RF, eds.), 1981: 165-172. |
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