71774-10-2

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71774-10-2 Structure

Identification	Back Directory
[Name] 12(S)-HPETE
[CAS] 71774-10-2
[Synonyms] 12(S)-HPETE 12(S)HpETE,12(S) HpETE ZIOZYRSDNLNNNJ-LQWMCKPYSA-N 12(S)-HpETE Lipid Maps MS Standard 12(S)-Hydroperoxy-eicosatetraenoic acid 12S-HYDROPEROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID (12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoic acid 12(S)-HYDROPEROXYEICOSA-5Z,8Z,10E,14Z-TETRAENOIC ACID (5Z,8Z,10Z,12S,14Z)-12-Hydroperoxy-5,8,10,14-icosatetraenoic acid (5Z,8Z,10E,12S,14Z)-12-Hydroperoxy-5,8,10,14-icosatetraenoic acid (5Z,8Z,10E,12S,14Z)-12-Hydroperoxyicosa-5,8,10,14-tetraenoic acid
[Molecular Formula] C20H32O4
[MDL Number] MFCD00063585
[MOL File] 71774-10-2.mol
[Molecular Weight] 336.47

Chemical Properties	Back Directory
[storage temp. ] Store at -20°C
[solubility ] 0.1 M Na2CO3: 2 mg/ml; DMF: Miscible; DMSO: Miscible; Ethanol: Miscible; PBS pH 7.2: 0.8 mg/ml
[form ] Liquid.

Safety Data	Back Directory
[Symbol(GHS) ] GHS02,GHS07
[Signal word ] Danger
[Hazard statements ] H225-H319
[Precautionary statements ] P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501

Hazard Information	Back Directory
[Description] 12(S)-HpETE is a monohydroperoxy polyunsaturated fatty acid (PUFA) produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It activates human blood leukocyte 5-LO, resulting in the synthesis of 5(S)-HETE, leukotriene B₄ (LTB₄), and 5(S),12(S)-DiHETE. Rat lung metabolizes 12(S)-HpETE to 8,11,12- and 10,11,12-trihydroxyeicostrienoic acids. 12(S)-HpETE is the mediator of many biological functions, including induction of c-fos and c-jun, activation of AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response to FMRF-amide in Aplysia sensory neurons and inhibits Ca²⁺/calmodulin-dependent protein kinase II from rat brain cortex.
[Uses] 12(S)-HPETE is a fatty acid and an activator of human blood leukocyte 5-LO.
[Definition] ChEBI: 12(S)-HPETE is the (S)-enantiomer of 12-HPETE. It has a role as a mouse metabolite. It is functionally related to an icosa-5,8,10,14-tetraenoic acid. It is a conjugate acid of a 12(S)-HPETE(1-). It is an enantiomer of a 12(R)-HPETE.

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