| Identification | Back Directory | [Name]
1-acetyl-3,2-toluyl-5-fluorouracil | [CAS]
71861-76-2 | [Synonyms]
A-?OT-?Fu
1-acetyl-3,2-toluyl-5-fluorouracil
1-Acetyl-3-o-toluyl-5-fluorouracil
2,4(1H,3H)-Pyrimidinedione, 1-acetyl-5-fluoro-3-(2-methylbenzoyl)- | [Molecular Formula]
C14H11FN2O4 | [MDL Number]
MFCD01689616 | [MOL File]
71861-76-2.mol | [Molecular Weight]
290.25 |
| Chemical Properties | Back Directory | [Melting point ]
141-143 °C(Solv: ethyl ether (60-29-7)) | [Boiling point ]
408.8±55.0 °C(Predicted) | [density ]
1.44±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
-5.29±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
1-Acetyl-3-o-toluyl-5-fluorouracil is a potent antitumor agent and a 5-fluorouracil analog. | [in vivo]
Oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil demonstrates a remarkable effect on MH134 solid tumors, the effect being more marked than that of subcutaneous administration of 1-Acetyl-3-o-toluyl-5-fluorouracil. Anti-tumor activity of oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at a dose of 0.2 mmol/kg/d is comparable to that of subcutaneous administration of 5-fluorouracil at the same dose. The level of decrease in thymus weight and the magnitude of increase of spleen weight following oral administration of 1-Acetyl-3-o-toluyl-5-fluorouracil at any dose are smaller than those by subcutaneous administration of 5-fluorouracil (0.2 mmol/kg/d)[1]. | [References]
[1] Yata N, et al. Anti-tumor activity of 1-acetyl-3-o-toluyl-5-fluorouracil against murine hepatoma MH134 and its effects on tissue weights following subcutaneous and oral administration. J Pharmacobiodyn. 1985 Apr;8(4):264-9. DOI:10.1248/bpb1978.8.264 |
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