| Identification | Back Directory | [Name]
METHYL 2-(2-AMINO-5-METHYL-1,3-THIAZOL-4-YL)ACETATE | [CAS]
72054-60-5 | [Synonyms]
2-amino-5-ethoxycarbonyl-4-methylthiazole
5-CHLORO-1,2,3,4-TETRAHYDRO-[2,6]NAPHTHYRIDINE
methyl 2-(2-amino-5-methylthiazol-4-yl)acetate
METHYL (2-AMINO-5-METHYL-1,3-THIAZOL-4-YL)ACETATE
METHYL 2-(2-AMINO-5-METHYL-1,3-THIAZOL-4-YL)ACETATE
4-Thiazolecarboxylic acid, 2-amino-5-methyl-, ethyl ester
METHYL 2-(2-AMINO-5-METHYL-1,3-THIAZOL-4-YL)ACETATE###72054-60-5 | [Molecular Formula]
C7H10N2O2S | [MDL Number]
MFCD00662517 | [MOL File]
72054-60-5.mol | [Molecular Weight]
186.23 |
| Chemical Properties | Back Directory | [Melting point ]
111-113°C | [Boiling point ]
313.1±22.0 °C(Predicted) | [density ]
1.283±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [pka]
3.08±0.10(Predicted) | [Appearance]
Light yellow to yellow Solid | [InChI]
InChI=1S/C7H10N2O2S/c1-3-11-6(10)5-4(2)12-7(8)9-5/h3H2,1-2H3,(H2,8,9) | [InChIKey]
KTGUPAFUVGHOQS-UHFFFAOYSA-N | [SMILES]
S1C(C)=C(C(OCC)=O)N=C1N |
| Hazard Information | Back Directory | [Synthesis]
Step 2: Synthesis of ethyl 2-amino-5-methylthiazole-4-carboxylate
Thiourea (47 g, 616.83 mmol) was added to a solution of ethyl 2-chloro-3-oxobutanoate (100 g, 577.19 mmol) in ethanol (1000 mL). The resulting mixture was stirred and reacted under reflux conditions for 2 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature in a water/ice bath. The precipitate was collected by filtration to give 105 g (93% yield) of ethyl 2-amino-5-methylthiazole-4-carboxylate as a light yellow solid. | [References]
[1] Patent: US2008/139558, 2008, A1. Location in patent: Page/Page column 51 |
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