| Identification | Back Directory | [Name]
BETA-CASOMORPHIN (BOVINE) | [CAS]
72122-62-4 | [Synonyms]
YPFPGPI
β-Casomorphin-7
BETA CASOMORPHIN
BETA-CASOMORPHIN-7
β-Casomorphin 7【ox】
β-Casomorphin-7【ox】
β-Casomorphin, bovine
β-Casomorphin(cattle)
b-Casomorphin (bovine)
BETA-CASOMORPHIN (BOVINE)
BETA-CASOMORPHIN-7 (BOVINE)
b-Casomorphin (1-7), bovine
TYR-PRO-PHE-PRO-GLY-PRO-ILE
β-Casomorphin (1-7), bovine
β-Casomorphin, bovine(2TFA)
L-TYR-PRO-PHE-PRO-GLY-PRO-ILE
BETA-CASOMORPHIN (1-7), BOVINE
Tyr-Pro-Phe-Pro-Gly-Pro-Ile-OH
H-TYR-PRO-PHE-PRO-GLY-PRO-ILE-OH
TYR-PRO-PHE-PRO-GLY-PRO-ILE 4H2O
BETA-CASOMORPHIN-7 (BOVINE) 4H2O
L-Tyr-L-Pro-L-Phe-L-Pro-Gly-L-Pro-L-Ile-OH
β-Casomorphin (bovine)|BETA-CASOMORPHIN (BOVINE)
β-Casomorphin (bovine)|BETA-CASOMORPHIN (BOVINE)
L-Isoleucine, L-tyrosyl-L-prolyl-L-phenylalanyl-L-prolylglycyl-L-prolyl- | [Molecular Formula]
C41H55N7O9 | [MDL Number]
MFCD00076323 | [MOL File]
72122-62-4.mol | [Molecular Weight]
789.92 |
| Hazard Information | Back Directory | [Uses]
β-Casomorphin, bovine (β-Casomorphin-7 (bovine) ) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay[1]. | [in vivo]
β-Casomorphin, bovine (7.5×10?6 mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats[3].
β-Casomorphin, bovine (7.5×10?6 mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats[3].
β-Casomorphin, bovine (7.5×10?6 mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats[3].
β-Casomorphin, bovine (7.5×10?6 mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells[3].
| Animal Model: | Male Sprague-Dawley (SD) rats (200 g±10 g)[3] | | Dosage: | 7.5×10?6 mol/day/kg | | Administration: | Oral gavage; for 30 days | | Result: | Increased plasma insulin and decreased plasma glucagon of diabetic rats. |
| [References]
[1] Brantl V, et al. Opioid activities of beta-casomorphins. Life Sci. 1981 Apr 27;28(17):1903-9. DOI:10.1016/0024-3205(81)90297-6
[2] Zoghbi S, et al. β-casomorphin-7-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13. DOI:10.1152/ajpgi.00455.2005
[3] Zhang W, et al. The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro. PLoS One. 2013 May 3;8(5):e63472. DOI:10.1371/journal.pone.0063472 |
|
|