| Chemical Properties | Back Directory | [Boiling point ]
1700.4±65.0 °C(predicted) | [density ]
1.147±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
13.42±0.46(predicted) | [Sequence]
{d-(Lys-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Lys)}-NH2 |
| Hazard Information | Back Directory | [Uses]
d-(KLAKLAK)2, as an antibacterial and anti-tumor polypeptide, is a representative of the antimicrobial peptide group, and also has good anticancer properties. d-(KLAKLAK)2 is able to kill bacteria by damaging their cell membranes, causing cell contents to leak out. d-(KLAKLAK)2 can also inhibit tumor cell proliferation by causing mitochondrial swelling and mitochondrial membrane destruction, triggering apoptosis (programmed cell death)[1]. | [References]
[1] Jaber S, et al. Synthesis, antitumor and antibacterial studies of new shortened analogues of (KLAKLAK) 2-NH2 and their conjugates containing unnatural amino acids[J]. Molecules, 2021, 26(4): 898. DOI:10.3390/molecules26040898 |
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YantaiBio
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13758194781 |
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