| Identification | Back Directory | [Name]
4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE | [CAS]
722-92-9 | [Synonyms]
2-(4-Amino-Phenyl
2-(4-Aminophenyl) hexafluoropropan-ol
2-(4-AMINOPHENYL)HEXAFLUORO-2-PROPANOL
4-(HEXAFLUORO-2-HYDROXYISOPROPYL)ANILINE
4-(Hexafluoro-2-hydroxyisopropyl)aniline97%
4-(Hexafluoro-2-hydroxyisopropyl)aniline 97%
4-Amino---Bis(Trifluoromethyl)Benzyl Alcohol
4-amino-à-à-bis(trifluoromethyl)benzyl alcohol
2-(4-AMINOPHENYL)-1,1,1,3,3,3-HEXAFLUORO-2-PROPANOL
4-(1,1,1,3,3,3-Hexafluoro-2-hydroxyprop-2-yl)aniline
2-(4-AMINO-PHENYL)-1,1,1,3,3,3-HEXAFLUORO-PROPAN-2-OL
4-AMINO-ALPHA,ALPHA-BIS(TRIFLUOROMETHYL)BENZYL ALCOHOL
2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol97%
2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol 97%
2-(4-Aminophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol,97%
benzenemethanol, 4-amino-alpha,alpha-bis(trifluoromethyl)-
2-(4-AMinophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol, 97% 5GR
4-(1,1,1,3,3,3-Hexafluoro-2-hydroxyprop-2-yl)aniline, 4-[Perfluoro(2-hydroxyprop-2-yl)]aniline | [Molecular Formula]
C9H7F6NO | [MDL Number]
MFCD00039258 | [MOL File]
722-92-9.mol | [Molecular Weight]
259.15 |
| Chemical Properties | Back Directory | [Appearance]
Light brown crystalline powder | [Melting point ]
147-152 °C
| [Boiling point ]
292.9±40.0 °C(Predicted) | [density ]
1.505±0.06 g/cm3(Predicted) | [storage temp. ]
Keep Cold under Argon | [form ]
Crystalline Powder | [pka]
9.86±0.15(Predicted) | [color ]
Light brown | [BRN ]
1473737 | [InChI]
InChI=1S/C9H7F6NO/c10-8(11,12)7(17,9(13,14)15)5-1-3-6(16)4-2-5/h1-4,17H,16H2 | [InChIKey]
TZEJXCIGVMTMDY-UHFFFAOYSA-N | [SMILES]
C(O)(C(F)(F)F)(C(F)(F)F)C1C=CC(N)=CC=1 |
| Questions And Answer | Back Directory | [Uses]
2-(4-aminobenzene)-1,1,1,3,3,3-hexafluoro-2-propanol can be used to prepare bisphenol AF. Bisphenol AF (hexafluorobisphenol A: 2,2-bis-(4-hydroxyphenyl)hexafluoropropane) is mainly used as a vulcanization accelerator for fluororubber. |
| Hazard Information | Back Directory | [Chemical Properties]
Light brown crystalline powder | [Synthesis]
To a xylene solution of aniline (7, 21.47 mmol) and p-toluenesulfonic acid (pTSA, 1.28 mmol) was added hexafluoroacetone trihydrate (8, 64.42 mmol) and the reaction mixture was heated to reflux for 5 hours. Upon completion of the reaction, it was cooled to room temperature to allow the product 4-(hexafluoro-2-hydroxyisopropyl)aniline (9) to crystallize and precipitate, which was collected by filtration and used directly in the next step of the reaction. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 6, p. 1638 - 1642
[2] European Journal of Medicinal Chemistry, 2016, vol. 122, p. 744 - 755
[3] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990, vol. 39, # 2.2, p. 323 - 328
[4] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1990, # 2, p. 383 - 389
[5] Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1990, vol. 39, # 2.2, p. 323 - 328 |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
37/39-26 | [RIDADR ]
2811 | [Hazard Note ]
Irritant/Keep Cold under Argon | [HazardClass ]
6.1 | [HazardClass ]
IRRITANT | [PackingGroup ]
Ⅲ | [HS Code ]
29221990 |
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