| Identification | Back Directory | [Name]
3-[2-(isopropylsulfanyl)ethyl] 5-(2-methoxyethyl) 4-{2-nitrophenyl}-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate | [CAS]
724737-08-0 | [Synonyms]
YG1702
3-(2-(isopropylthio)ethyl) 5-(2-methoxyethyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
3-[2-(isopropylsulfanyl)ethyl] 5-(2-methoxyethyl) 4-{2-nitrophenyl}-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-(2-methoxyethyl) 5-[2-[(1-methylethyl)thio]ethyl] ester | [Molecular Formula]
C23H30N2O7S | [MOL File]
724737-08-0.mol | [Molecular Weight]
478.56 |
| Chemical Properties | Back Directory | [Boiling point ]
602.5±55.0 °C(Predicted) | [density ]
1.220±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
2.58±0.70(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
YG1702 is a potent ALDH18A1-specific inhibitor. YG1702 attenuates the growth of MYCN-amplified NB and down-regulates MYCN. YG1702 physically interacts with ALDH18A1 with a high affinity and might potentially affect its enzymatic activity[1]. | [in vivo]
YG1702 (intraperitoneal injection (I.P.), 45 mg/kg, once every 3 days, three times) inhibits the growth of the xenografts in tumor-bearing mice[1]. | Animal Model: | NOD/SCID mice (5-6-week-old female)[1] | | Dosage: | 45 mg/kg | | Administration: | Intraperitoneal injection (I.P.), once every 3 days, three times | | Result: | Inhibited the growth of the xenografts in tumor-bearing mice. |
| [References]
[1] Guo YF, et al. Inhibition of the ALDH18A1-MYCN positive feedback loop attenuates MYCN-amplified neuroblastoma growth. Sci Transl Med. 2020 Feb 19;12(531):eaax8694. DOI:10.1126/scitranslmed.aax8694 |
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