| Chemical Properties | Back Directory | [Boiling point ]
617.4±55.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml | [form ]
A crystalline solid | [pka]
4.10±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
NSC 15520 is an inhibitor of replication protein A 70 (RPA70) dsDNA binding.1 It selectively inhibits dsDNA over ssDNA binding to RPA70 when used at concentrations ranging from 25 to 400 μM. NSC 15520 also inhibits the protein-protein interaction between the cell cycle checkpoint control proteins p53 or Rad9 and RPA70. | [Uses]
NSC15520 is a small molecular inhibitor of Replication Protein A (RPA). NSC15520 specifically recognizes the RPA N-terminal DNA binding domain (DBD), and blocks the interaction of RPA with p53 or RAD9. NSC15520 also inhibtis helix destabilization of a duplex DNA (dsDNA) oligonucleotide, involves in DNA replication, DNA repair, DNA recombination, and DNA damage response signaling[1]. | [storage]
Store at -20°C | [References]
1. Glanzer, J.G., Liu, S., and Oakley, G.G. Small molecule inhibitor of the RPA70 N-terminal protein interaction domain discovered using in silico and in vitro methods Bioorg. Med. Chem. 19(8),2589-2595(2011). |
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| Company Name: |
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| Tel: |
4008-099-669 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList112975/0.htm |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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