| Identification | Back Directory | [Name]
(S)-2,4-Diaminobutanoic acid hydrobromide | [CAS]
73143-97-2 | [Synonyms]
L-2,4-DIAMINOBUTYRIC ACID HBR
(S)-2,4-Diaminobutanoic acid hydrobromide | [Molecular Formula]
C4H11BrN2O2 | [MDL Number]
MFCD07368664 | [MOL File]
73143-97-2.mol | [Molecular Weight]
199.046 |
| Hazard Information | Back Directory | [Uses]
L-DABA (L-2,4-Diaminobutyric acid) hydrobromide is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro. | [in vivo]
Treatment with L-DABA hydrobromide results in 43.4% reduction of tumor growth[1]. L-DABA hydrobromide is a more effective inhibitor of GABA transaminase in vivo than in vitro[2]. | [storage]
Store at -20°C | [References]
[1] Ronquist G, et al. Antitumor activity of L-2,4 diaminobuturic acid against mouse fibrosarcoma cells in vitro and in vivo. J Cancer Res Clin Oncol. 1980;96(3):259-68. DOI:10.1007/BF00408098
[2] Beart PM, et al. l-2,4-Diaminobutyric acid and the GABA system. Neurosci Lett. 1977 Jul;5(3-4):193-8. DOI:10.1016/0304-3940(77)90046-5
[3] Panasci L, et al. The cytolytic effect of L-2,4 diaminobutyric acid with malignant glioma cells and fibroblasts. Cancer Chemother Pharmacol. 1988;21(2):143-4. DOI:10.1007/BF00257361 |
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3A Chemicals
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400-668-9898 |
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www.3achem.com |
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