| Identification | Back Directory | [Name]
GOT1 inhibitor 2c | [CAS]
732973-87-4 | [Synonyms]
GOT1 inhibitor-1
GOT1 inhibitor 2c
N-(4-chlorophenyl)-4-(1H-indol-4-yl)piperazine-1-carboxamide | [Molecular Formula]
C19H19ClN4O | [MDL Number]
MFCD31933835 | [MOL File]
732973-87-4.mol | [Molecular Weight]
354.83 |
| Chemical Properties | Back Directory | [Boiling point ]
639.5±55.0 °C(Predicted) | [density ]
1.387±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 125 mg/mL (352.28 mM) | [form ]
Solid | [pka]
13.07±0.70(Predicted) | [color ]
Off-white to light yellow | [Water Solubility ]
Water: < 0.1 mg/mL (insoluble) |
| Hazard Information | Back Directory | [Uses]
GOT1 inhibitor-1 (compound 2c), a tryptamine-based derivative, acts as a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. GOT1 plays an important role in energy metabolism and Reactive Oxygen Species (ROS) balance. GOT1 inhibitor-1 can be used for the research of pancreatic ductal adenocarcinoma (PDAC)[1]. | [References]
[1] Justin Anglin, et al. Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma. Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678 DOI:10.1016/j.bmcl.2018.04.061
[2] Sun W, et al. Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism. Cell Commun Signal. 2019;17(1):111. DOI:10.1186/s12964-019-0425-4 |
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| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
| Website: |
www.chemicalbook.com/showsupplierproductslist927327/0_en.htm |
| Company Name: |
InvivoChem
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| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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