| Identification | Back Directory | [Name]
BAY 61-3606 | [CAS]
732983-37-8 | [Synonyms]
CS-2745
BAY-61-360
BAY 61-3606
SYK INHIBITOR IV
BAY 61-3606 free base
Syk Inhibitor IV, BAY 61-3606
Syk Inhibitor IV, BAY 61-3606 HCl
BAY 61-3606 hydrate hydrochloride
Syk Inhibitor IV,
BAY 61-3606: sc-202351
hydrochloride
2-[[7-(3,4-Dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]-3-pyridinecarboxamide
3-Pyridinecarboxamide, 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]- | [Molecular Formula]
C20H18N6O3 | [MDL Number]
MFCD18641826 | [MOL File]
732983-37-8.mol | [Molecular Weight]
390.4 |
| Hazard Information | Back Directory | [Uses]
Syk Inhibitor IV is an imidazopyrimidine inhibitor of Syk and Syk-mediated functions. | [Definition]
ChEBI: 2-[[7-(3,4-dimethoxyphenyl)-5-imidazo[1,2-c]pyrimidinyl]amino]-3-pyridinecarboxamide is a member of pyrimidines. | [Biological Activity]
Cell permeable: yes''Primary Target
Syk''Product competes with ATP.''Reversible: yes | [in vivo]
Bay 61-3606 (50 mg/kg; administered twice a week for two weeks by intraperitoneal injection) alone leads to more efficacious reductions than that of TNF-related apoptosis-inducing ligand (TRAIL; 10 mg/kg) alone in MCF-7 tumor xenograft-bearing BALB/c nude mice. Bay 61-3606 administered in TRAIL combination significantly reduces the volume of the xenografted tumor[4]. | Animal Model: | Female BALB/c nude mice (5 weeks old) bearing MCF-7 tumor xenograft[4] | | Dosage: | 50 mg/kg | | Administration: | Injected intraperitoneally twice a week with Bay 61-3606 (50 mg/kg), TRAIL (10 mg/kg) or a combination of Bay 61-3606 (50 mg/kg) and TRAIL (10 mg/kg); TRAIL was given 2 h after the injection of Bay 61-3606; for two weeks | | Result: | Led to efficacious reductions in tumor growth. |
| [storage]
Store at -20°C |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
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