| Hazard Information | Back Directory | [Description]
S 16924 is a novel, potential antipsychotic with marked serotonin1A agonist properties. | [Uses]
(Rac)-S 16924 is a partial agonist of the 5-HT1A receptor. (Rac)-S 16924 regulates signaling through its interaction with the 5-HT1A receptor, and (Rac)-S 16924 can stabilize the receptor in its G-protein-coupled conformation without fully activating it, which may affect intracellular signaling pathways associated with this receptor. (Rac)-S 16924 can be used to study the 5-HT1A receptor in mental disorders, especially schizophrenia[1]. | [References]
[1] Newman-Tancredi A, et al. Efficacy of antipsychotic agents at human 5-HT1A receptors determined by [3H] WAY100, 635 binding affinity ratios: relationship to efficacy for G-protein activation[J]. European journal of pharmacology, 2001, 428(2): 177-184. DOI:10.1016/s0014-2999(01)01344-9 |
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