| Identification | Back Directory | [Name]
(-)-BICUCULLINE METHOBROMIDE | [CAS]
73604-30-5 | [Synonyms]
Bicuculineracemic
Bicuculinemethoiodide
l-Bicuculline methobromide
(-）Bicucullinemethobromide
(-)-BICUCULLINE METHOBROMIDE
(-)-BICUCULLINE 1(S),9(R) METHBROMIDE
(R-(R*,S*))-5-(6,8-Dihydro-8-oxofuro[3.4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4.5-g]isoq
(6R)-6-[(5R)-6,6-diMethyl-7,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolin-6-iuM-5-yl]-6H-furo[3,2-g][1,3]benzodioxol-7-one broMide
[R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide
[R-(R*,S*)]-5-(6,8-DIHYDRO-8-OXOFURO[3,4-E]-1,3-BENZODIOXOL-6-YL)-5,6,7,8-TETRAHYDRO-6,6-DIMETHYL-1,3-DIOXOLO[4,5-G]ISOQUINDINIUM BROMIDE
[R-(R*,S*)]-5-(6,8-DIHYDRO-8-OXOFURO[3,4-E]-1,3-BENZODIOXOL-6-YL)-5,6,7,8-TETRAHYDRO-6,6-DIMETHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLINIUM BROMIDE | [Molecular Formula]
C21H20BrNO6 | [MDL Number]
MFCD00055149 | [MOL File]
73604-30-5.mol | [Molecular Weight]
462.29 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C
| [solubility ]
aqueous base: unstable
| [form ]
solid
| [color ]
white
| [Water Solubility ]
Soluble in water (50mM) | [Sensitive ]
Light Sensitive |
| Hazard Information | Back Directory | [Uses]
(-)-Bicuculline methobromide is an N-methylated derivative of the GABAA?antagonist bicuculline. | [Biological Activity]
Methobromide salt of (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported. | [in vivo]
(-)-Bicuculline methobromide can be used in animal modeling to create epilepsy models and is capable of crossing the blood-brain barrier[3].
1. Induction of epilepsy[3] Background
(-)-Bisculline methoromide can inhibit the synthesis and release of GABA, and weaken GABA's inhibition of neuronal activity in the SN reticular region (SNr), leading to epilepsy.
Specific Mmodeling Methods
Rat: Sprague-Dawley (SD) ? male or female ? 2 weeks old
Administration: 12.5, 25, 50 or 100 ng/0.25 μL ? inject into SN or corpus striatum through bilateral catheter implantation
Note
(1) Dissolve (-)-Bicuculine methoromide in distilled water and administer at a volume of 0.25 μL.
(2) Simultaneously administer bilateral infusions at a rate of 0.25 μ L/min, and after the infusion is completed, insert the catheter in situ for an additional minute to prevent drug reflux.
(3) Due to the short-lived effect of (-) - Bicuculine methoromide in SN, rats were tested 5 minutes after completing the infusion.
Modeling Indicators Behavioral observation: Shortened the latency period of epileptic seizures, causing stereotyped behaviors such as excessive sniffing or licking, chewing movements, head twitching, and slow or occasional circling.
Correlated Product(s): Muscimol (HY-N2313) Opposite Product(s): / | Animal Model: | Rat L5-SNL model[2] | | Dosage: | 0.6 nmol/rat | | Administration: | Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.) | | Result: | Attenuated the antiallodynic effect of Neurotropin. |
| [storage]
Store at 2-8°C |
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