| Identification | Back Directory | [Name]
NSC 98778 | [CAS]
737-76-8 | [Synonyms]
NSC 98778
5'-Azidoadenosine
5'-Deoxy-5'-azidoadenosine
5'-Azido-5'-deoxyadenosine | [Molecular Formula]
C10H12N8O3 | [MDL Number]
MFCD31707474 | [MOL File]
737-76-8.mol | [Molecular Weight]
292.254 |
| Hazard Information | Back Directory | [Uses]
5′-Azido-5′-deoxyadenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1]. 5′-Azido-5′-deoxyadenosine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [References]
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005 |
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