| Identification | Back Directory | [Name]
Pyrimidine, 4-[(2,4-dinitrophenyl)thio]- | [CAS]
73768-68-0 | [Synonyms]
Pyrimidine, 4-[(2,4-dinitrophenyl)thio]- | [Molecular Formula]
C10H6N4O4S | [MOL File]
73768-68-0.mol | [Molecular Weight]
278.24 |
| Chemical Properties | Back Directory | [Melting point ]
156-158 °C(Solv: methanol (67-56-1)) | [Boiling point ]
458.5±40.0 °C(Predicted) | [density ]
1.60±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
0.08±0.18(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Description]
NSC-311068 is a novel selective inhibitor of TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification, effectively inhibiting cell viability in AML with high expression of TET1. | [Uses]
NSC-311068 is TET1 inhibitor. NSC-311068 selectively suppress TET1 transcription and 5-hydroxymethylcytosine (5hmC) modification. NSC-311068 represses the level of TET1 expression and the global 5hmC level. NSC-311068 effectively inhibits cell viability in AML cells with high expression of TET1[1]. | [References]
[1] Jiang X, et al. Targeted inhibition of STAT/TET1 axis as a therapeutic strategy for acute myeloid leukemia. Nat Commun. 2017 Dec 13;8(1):2099. DOI:10.1038/s41467-017-02290-w |
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