| Identification | Back Directory | [Name]
4-AMinothiophene-2-carbonitrile | [CAS]
73781-74-5 | [Synonyms]
4-AMinothiophene-2-carbonitrile
4-amino-2-Thiophenecarbonitrile
2-Thiophenecarbonitrile, 4-amino- | [Molecular Formula]
C5H4N2S | [MOL File]
73781-74-5.mol | [Molecular Weight]
124.164 |
| Chemical Properties | Back Directory | [Boiling point ]
352.6±22.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2–8 °C | [pka]
2.45±0.10(Predicted) | [Appearance]
Light brown to reddish brown Solid |
| Questions And Answer | Back Directory | [Application]
Protein arginine methyltransferase (PRMT) inhibitors can be used to treat proliferative, inflammatory, infectious, and immunomodulatory diseases, including cancer, asthma, COPD, allergic diseases, rheumatoid arthritis, spinal muscular atrophy, atherosclerosis and psoriasis, viral infections, solid organ transplant rejection, osteoarthritis, and inflammatory bowel syndrome. A series of novel protein arginine methyltransferase (PRMT) inhibitor compounds are described in patent WO2008104077. |
| Hazard Information | Back Directory | [Synthesis]
Step 3 Synthesis of 4-aminothiophene-2-carbonitrile (3): 4-nitrothiophene-2-carbonitrile (2) (100 mg, 0.65 mmol) was dissolved in ethyl acetate (4 mL) and dioxane (0.2 mL) and 5% Pd/C catalyst (77 mg) was added. After 16 h of reaction under hydrogen atmosphere, 10% Pd/C Degussa wet catalyst (30 mg) was added and stirring was continued for 24 h under hydrogen at 1 atmosphere. Upon completion of the reaction, the catalyst was removed by diatomaceous earth filtration and the filtrate was concentrated under vacuum. The product was purified by column chromatography using 20-30% ethyl acetate/hexane as eluent to give 4-aminothiophene-2-carbonitrile (3).LRMS (ESI) Calculated value: 124.2, Measured value: 125.1 (MH)+. | [References]
[1] Patent: WO2008/104077, 2008, A1. Location in patent: Page/Page column 46; 47 |
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| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
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