| Identification | Back Directory | [Name]
cimoxatone | [CAS]
73815-11-9 | [Synonyms]
MD-780515
cimoxatone
3-[[4-[5-(Methoxymethyl)-2-oxooxazolidin-3-yl]phenoxy]methyl]benzonitrile
Benzonitrile, 3-[[4-[5-(methoxymethyl)-2-oxo-3-oxazolidinyl]phenoxy]methyl]-
3-[[4-[5-(methoxymethyl)-2-oxo-1,3-oxazolidin-3-yl]phenoxy]methyl]benzonitrile | [EINECS(EC#)]
277-613-7 | [Molecular Formula]
C19H18N2O4 | [MDL Number]
MFCD00867655 | [MOL File]
73815-11-9.mol | [Molecular Weight]
338.36 |
| Chemical Properties | Back Directory | [Boiling point ]
474.51°C (rough estimate) | [density ]
1.2855 (rough estimate) | [refractive index ]
1.6140 (estimate) | [pka]
0.25±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
Cimoxatone is a monoamine oxidase form A (MAO-A) selective inhibitor which shows adverse effects in combination with Tyramine. | [in vivo]
Cimoxatone (20 mg/kg; p.o.) enhances the anorectic action of 5-HT (1 mg/kg; s.c.) in rats[1]. | Animal Model: | 250-300 g, Adult male Wistar rats[1] | | Dosage: | 20 mg/kg | | Administration: | P.o. | | Result: | Significiantly reduced sucrose intake induced by 1 mg/kg 5-HT or its vehicle injected 2 and 24 h later, significantly enhanced the anorectic action of 5-HT at 2 h but not at 24 h. |
| [IC 50]
MAO-A |
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