| Identification | Back Directory | [Name]
Hydrocortisone | [CAS]
74050-20-7 | [Synonyms]
Efficort
Suniderma
hydrocortisone aceponate
Hydrocortisonepropylacetate
Methylprednisolone Impurity 45
Hydrocortisone 17-Propionate 21-Acetate
Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11-hydroxy-17-(1-oxopropoxy)-, (11β)-
[(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-11-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate
[(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetyloxyethanoyl)-11-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate
propionic acid [(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-11-hydroxy-3-keto-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] ester | [Molecular Formula]
C26H36O7 | [MDL Number]
MFCD00866010 | [MOL File]
74050-20-7.mol | [Molecular Weight]
460.56 |
| Chemical Properties | Back Directory | [Melting point ]
144-146°C | [density ]
1.23±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Pale Beige | [InChIKey]
MFBMYAOAMQLLPK-VRVFYZPPNA-N | [SMILES]
[C@@]1(OC(=O)CC)(C(=O)COC(=O)C)CC[C@@]2([H])[C@]3([H])CCC4=CC(=O)CC[C@]4(C)[C@@]3([H])[C@@H](O)C[C@]12C |&1:0,15,17,27,29,31,34,r| |
| Hazard Information | Back Directory | [Description]
Hydrocortisone aceponate is the 17-a-propionate derivative of hydrocortisone-21-acetate.
Its is reportedly significantly superior to the latter in the treatment of dermatoses of
varying severity. | [Chemical Properties]
White to Off-White Solid | [Originator]
Beiersdorf (W.Germany) | [Uses]
A new topical hydrocortisone derivative with esterification in positions 17 and 21, inhibit the incorporation of [3H]thymidine in DNA in human skin fibroblasts less strongly than the halogenated glucocorticosteroids betamethasone 17-valerate and clobetasol 17-propionate. Glucocorticosteroid | [Definition]
ChEBI: Hydrocortisone aceponate is a corticosteroid hormone. | [Brand name]
Retef | [Synthesis]
Hydrocortisone was prepared as follows: 1 8 g of hydrocortisone was dissolved in 18 ml of anhydrous dimethylformamide and treated with 16 ml of triethyl orthopropionate. After addition of 60 mg of p-toluenesulfonic acid 1H 2 O, the reaction mixture was st |
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