| Identification | Back Directory | [Name]
6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propen-1-yl)-1H-3-Benzazepine-7,8-diol hydrobromide | [CAS]
74115-10-9 | [Synonyms]
SKF83822 hydrobromide,SKF-83822 hydrobromide
N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide
6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propen-1-yl)-1H-3-Benzazepine-7,8-diol hydrobromide | [Molecular Formula]
C20H23BrClNO2 | [MDL Number]
MFCD07773055 | [MOL File]
74115-10-9.mol | [Molecular Weight]
424.759 |
| Chemical Properties | Back Directory | [Melting point ]
265-267 °C | [storage temp. ]
Store at RT | [solubility ]
Soluble to 10 mM in ethanol and to 100 mM in DMSO | [form ]
Powder | [InChI]
1S/C20H22ClNO2.BrH/c1-3-8-22-9-7-15-16(11-18(23)20(24)19(15)21)17(12-22)14-6-4-5-13(2)10-14;/h3-6,10-11,17,23-24H,1,7-9,12H2,2H3;1H | [InChIKey]
CFWPKYBBXBANLU-UHFFFAOYSA-N | [SMILES]
Br.Cc1cccc(c1)C2CN(CCc3c(Cl)c(O)c(O)cc23)CC=C |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS06,GHS09 | [Signal word ]
Danger | [Hazard statements ]
H301-H400 | [Precautionary statements ]
P273-P301+P310+P330 | [Hazard Codes ]
T,N | [Risk Statements ]
25-50/53 | [Safety Statements ]
45-60-61 | [RIDADR ]
UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral
Aquatic Acute 1 |
| Hazard Information | Back Directory | [Uses]
SKF 83822 Hydrobromide is a potent agonist of peripheral dopamine receptors. | [Definition]
ChEBI: A hydrobromide salt prepared from N-allyl-6-chloro-1-(3-methylphenyl)-2,3,4,5-tetrahydro-3-benzazepine-7,8-diol and one equivalent of hydrogen bromide. High affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 1
6, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, alpha1A and alpha1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal
nd hyperlocomotion following subcutaneous administration in monkeys. | [Biological Activity]
SKF83822 is a dopamine receptor agonist th at only activates the D1 monomers and stimulates adenylate cyclasebut not PI hydrolysis. | [in vivo]
SKF83822 activates dopamine D1 receptors coupled to Gαs/olf and downstream cyclase activity. SKF83822 produces a locomotor response in both rodent and non-human primate models without affecting stereotypy, intense grooming, or dyskinesia. An acute injection of SKF83822 (0.4 mg/kg; i.p.) induced a greater than threefold increase in locomotor activity relative to the baseline period for each genotype[1]. | Animal Model: | Gαq knockout mice[1] | | Dosage: | 0.4 mg/kg | | Administration: | | | Result: | There was a significant increase in locomotor activity in each genotype.
|
| [IC 50]
D1 Receptor | [storage]
Store at RT |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|