| Identification | Back Directory | [Name]
Phortress free base | [CAS]
741241-36-1 | [Synonyms]
Phortress free base
Hexanamide, 2,6-diamino-N-[4-(5-fluoro-2-benzothiazolyl)-2-methylphenyl]-, (2S)-
(2S)-2,6-diamino-N-[4-(5-fluoro-1,3-benzothiazol-2-yl)-2-methyl-phenyl]hexanamide | [Molecular Formula]
C20H23FN4OS | [MDL Number]
MFCD06407804 | [MOL File]
741241-36-1.mol | [Molecular Weight]
386.49 |
| Hazard Information | Back Directory | [Uses]
Phortress free base (NSC 710305) is a P450 CYP1A1-activated antitumor prodrug with antitumor activity[1]. Phortress free base leads to DNA damage and cell cycle arrest[2]. | [IC 50]
CYP1 | [References]
[1] Behrsing HP, et al. In vitro exposure of precision-cut lung slices to 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole lysylamide dihydrochloride (NSC 710305, Phortress) increases inflammatory cytokine content and tissue damage. Toxicol Sci. 2013 Feb;131(2):470-9. DOI:10.1093/toxsci/kfs319
[2] Trapani V, et al. DNA damage and cell cycle arrest induced by 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203, NSC 703786) is attenuated in aryl hydrocarbon receptor deficient MCF-7 cells. Br J Cancer. 2003 Feb 24;88(4):599-605. DOI:10.1038/sj.bjc.6600722 |
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