| Identification | Back Directory | [Name]
4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester | [CAS]
74447-88-4 | [Synonyms]
PQQ-TME
Pqq trimethyl ester
Methoxatin trimethyl ester
Coenzyme pqq trimethyl ester
Trimethyl 4,5-dihydro-4,5-dioxo-1H-pyrrolo(2,3-F)quinoline-2,7,9-tricarboxylate
4,5-Dioxo-4,5-dihydro-1H-pyrrol[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester
4,5-Dioxo-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid trimethyl ester
1H-Pyrrolo(2,3-F)quinoline-2,7,9-tricarboxylic acid, 4,5-dihydro-4,5-dioxo-, trimethyl ester | [Molecular Formula]
C17H12N2O8 | [MDL Number]
MFCD01939036 | [MOL File]
74447-88-4.mol | [Molecular Weight]
372.286 |
| Hazard Information | Back Directory | [Uses]
PQQ-trimethylester (PQQ-TME) is a synthetic compound that is a trimethylester derivative of pyrroloquinoline quinone (PQQ). PQQ-trimethylester has twice the blood-brain barrier permeability of PQQ (HY-100196) in vitro. In addition, PQQ-trimethylester shows strong inhibitory activity against α-synuclein, amyloid β1-42 (Aβ1-42) and prion protein fibrillation. PQQ-trimethylester can be used in the study of neurodegenerative diseases[1]. | [IC 50]
α-synuclein Aggregation | [References]
[1] Tsukakoshi K, et al. Esterification of PQQ enhances blood-brain barrier permeability and inhibitory activity against amyloidogenic protein fibril formation[J]. ACS Chemical Neuroscience, 2018, 9(12): 2898-2903. DOI:10.1021/acschemneuro.8b00355 |
|
| Company Name: |
Best west lab
|
| Tel: |
(801)415-9463 |
| Website: |
www.bestwestlab.com |
|