| Identification | Back Directory | [Name]
NVX-207 | [CAS]
745020-66-0 | [Synonyms]
NVX-207
NVX 207,NVX207
Lup-20(29)-en-28-oic acid, 3-(acetyloxy)-, 2-amino-3-hydroxy-2-(hydroxymethyl)propyl ester, (3β)- | [Molecular Formula]
C36H59NO6 | [MOL File]
745020-66-0.mol | [Molecular Weight]
601.87 |
| Chemical Properties | Back Directory | [Boiling point ]
664.8±55.0 °C(Predicted) | [density ]
1.14±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (207.69 mM) | [form ]
Solid | [pka]
11.71±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
NVX-207, a Betulinic acid-derived anti-cancer compound, shows anti-tumor activity (mean IC50=3.5 μM) against various human and canine cell lines. NVX-207-induced apoptosis is associated with activation of the intrinsic apoptotic pathway via cleavage of caspases -9, -3, -7 and of PARP[1]. | [in vivo]
Intravenous application of NVX-207 in mice is well tolerated[1]. | [storage]
Store at -20°C | [References]
[1] Willmann M, et al. Characterization of NVX-207, a novel betulinic acid-derived anti-cancer compound. Eur J Clin Invest. 2009;39(5):384-394. DOI:10.1111/j.1365-2362.2009.02105.x
[2] Bache M, et al. Betulinic acid derivatives NVX-207 and B10 for treatment of glioblastoma--an in vitro study of cytotoxicity and radiosensitization. Int J Mol Sci. 2014 Oct 30;15(11):19777-90. DOI:10.3390/ijms151119777 |
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