| Identification | Back Directory | [Name]
Ditercalinium | [CAS]
74517-42-3 | [Synonyms]
NSC-366241
NSC-335153
Ditercalinium
2,2'-[4,4'-Bipiperidine-1,1'-diylbis(ethylene)]bis[10-methoxy-7H-pyrido[4,3-c]carbazol-2-ium] | [Molecular Formula]
C46H50Cl2N6O2 | [MOL File]
74517-42-3.mol | [Molecular Weight]
789.834 |
| Hazard Information | Back Directory | [Uses]
Ditercalinium chloride is an anticancer agent. Ditercalinium chloride inhibits human DNA polymerase gamma activity. Ditercalinium chloride can deplete mitochondrial DNA in both mouse and human cells. Ditercalinium chloride is a potential ligand against the COMMD10-AP3S1 fusion protein[1][2]. | [References]
[1] Okamaoto M, et al. Ditercalinium chloride, a pro-anticancer drug, intimately associates with mammalian mitochondrial DNA and inhibits its replication. Curr Genet. 2003 Aug;43(5):364-70. DOI:10.1007/s00294-003-0393-4
[2] Sandhya Rai, et al. Ditercalinium chloride: A potential inhibitor targeting recurrent in frame COMMD10-AP3S1 fusions in CRCs. Gene Reports. 2023, 30:101739. |
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