| Identification | Back Directory | [Name]
Docarpamine | [CAS]
74639-40-0 | [Synonyms]
TA 870
TA-8704
Tanadopa
Docarpamine
3,4-Bis[(ethoxycarbonyl)oxy]-N-(N-acetyl-L-methionyl)benzeneethanamine
4-{2-[(N-Acetyl-L-methionyl)amino]ethyl}-1,2-phenylenediethylbiscarbonate
(S)-2-(Acetylamino)-N-[3,4-bis(ethoxycarbonyloxy)phenethyl]-4-(methylthio)butanamide
Carbonic acid, 4-[2-[[(2S)-2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester
Carbonic acid, 4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene diethyl ester, (S)-
Carbonic acid, C,C'-[4-[2-[[2-(acetylamino)-4-(methylthio)-1-oxobutyl]amino]ethyl]-1,2-phenylene] C,C'-diethyl ester | [Molecular Formula]
C21H30N2O8S | [MDL Number]
MFCD00867115 | [MOL File]
74639-40-0.mol | [Molecular Weight]
470.54 |
| Chemical Properties | Back Directory | [Melting point ]
85-90°; mp 105-108° (Nishiyama, 1992) | [alpha ]
D20 -15.6° (c = 2 in methanol) | [Boiling point ]
731.0±60.0 °C(Predicted) | [density ]
1.222±0.06 g/cm3(Predicted) | [pka]
14.51±0.46(Predicted) |
| Hazard Information | Back Directory | [Description]
Docarpamine is a cardiostimulant with diuretic activity launched in Japan for the
treatment of circulatory insufficiency. It is an orally effective peripheral dopamine
prodrug that is well absorbed from the gastrointestinal tract and converted to
dopamine in vivo, which exerts renal vasodilatory and natriuretic effects by
activating renal dopamine (DA1) receptors, and a positive inotropic effect by
activating cardiac β1-receptors. It has been reported to be effective in treating
patients with acute heart failure, shock and acute renal failure. | [Originator]
Tanabe Seiyaku (Japan) | [Uses]
Docarpamine maybe a usefule alternative to intravenous dopamine after cardiac surgery. | [Definition]
ChEBI: Docarpamine is an organic molecular entity. | [Brand name]
Tanadopa |
| Safety Data | Back Directory | [Toxicity]
LD50 in male, female rats (mg/kg): 1000-1400, ~1000 s.c.; in rats, dogs (mg/kg): _>2000 orally (Nishiyama, 1992) |
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