| Identification | Back Directory | [Name]
4-PhenylpyriMidine-2-carboxylic acid | [CAS]
74647-39-5 | [Synonyms]
4-Phenyl-2-pyrimidinecarboxylicacid
4-PhenylpyriMidine-2-carboxylic acid
6-phenylpyriMidine-2-carboxylic acid
2-Pyrimidinecarboxylic acid, 4-phenyl- | [Molecular Formula]
C11H8N2O2 | [MDL Number]
MFCD16988171 | [MOL File]
74647-39-5.mol | [Molecular Weight]
200.19 |
| Chemical Properties | Back Directory | [Melting point ]
154-156 °C(Solv: benzene (71-43-2)) | [Boiling point ]
468.2±38.0 °C(Predicted) | [density ]
1.302±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [pka]
3.02±0.10(Predicted) |
| Hazard Information | Back Directory | [Synthesis]
4-Substituted phenylpyrimidine-2-carboxamide (0.025 mol) was mixed with 20% sulfuric acid solution (100 mL) and the reaction was heated at 100 °C for 5-10 h. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction mixture was poured into an ice/water mixture under vigorous stirring, followed by collection of the precipitate by filtration and drying to give 4-substituted phenylpyrimidine-2-carboxylic acid as a light yellow solid. | [References]
[1] European Journal of Medicinal Chemistry, 2013, vol. 69, p. 77 - 89
[2] Patent: CN104072480, 2016, B. Location in patent: Paragraph 0239; 0240
[3] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 23, p. 6166 - 6173 |
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| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Wuhan Topule
|
| Tel: |
+86-02787215551 +86-19945035818 |
| Website: |
http://www.topule.com/ |
| Company Name: |
Shanghai UCHEM Inc.
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| Tel: |
18939844854 |
| Website: |
www.chemicalbook.com/supplier/23967788/ |
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