| Identification | Back Directory | [Name]
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid | [CAS]
74711-43-6 | [Synonyms]
Soleton
Salafapinon
ZALTOPROFEN
Einecs 277-973-5
Zaltoprofen, >=99%
Zaltoprofen (unspecified)
CN100;SOLETON;CN-100;CN 100
Dibenzo[b,f]Thiepin-2-Acetic Acid
10,11-Dihydro-alpha-Methyl-10-oxo-dibenzo
2-(6-oxo-5H-benzo[b][1]benzothiepin-3-yl)propanoic acid
10,11-dihydro-α-methyl-10-oxodibenzo[b,f]thiepin-2-acetic acid
2-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid
3-(10-Oxo-10,11-dihydrodibenzo[b,f]thiepin-2-yl)propanoic acid
Dibenzo[b,f]thiepin-2-acetic acid, 10,11-dihydro-α-methyl-10-oxo-
Dibenzo[b,f]thiepin-2-acetic acid, 10,11-dihydro-a-methyl-10-oxo-
10,11-dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
Dibenzo(B,F)thiepin-2-acetic acid, 10,11-dihydro-alpha-methyl-10-oxo-
10,11-Dihydro-alpha-methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid USP/EP/BP
Zaltoprofen/ 10,11-Dihydro-alpha-Methyl-10-oxo-dibenzo[b,f]thiepin-2-acetic acid
CAS No:74711-43-6 Dibenzo[b,f]thiepin-2-aceticacid, 10,11-dihydro-a-Methyl-10-oxo- | [EINECS(EC#)]
277-973-5 | [Molecular Formula]
C17H14O3S | [MDL Number]
MFCD00864323 | [MOL File]
74711-43-6.mol | [Molecular Weight]
298.36 |
| Chemical Properties | Back Directory | [Melting point ]
129-1310C | [Boiling point ]
500.5±50.0 °C(Predicted) | [density ]
1.329±0.06 g/cm3(Predicted) | [storage temp. ]
Refrigerator | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
4.21±0.10(Predicted) | [color ]
Off-White to Pale Yellow | [Merck ]
14,10112 | [InChI]
InChI=1S/C17H14O3S/c1-10(17(19)20)11-6-7-15-12(8-11)9-14(18)13-4-2-3-5-16(13)21-15/h2-8,10H,9H2,1H3,(H,19,20) | [InChIKey]
MUXFZBHBYYYLTH-UHFFFAOYSA-N | [SMILES]
C(C1=CC=C2SC3=CC=CC=C3C(CC2=C1)=O)(C)C(=O)O |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White to Pale Yellow Solid | [Uses]
Anti-inflammatory activity resides in (S)-enantiomer. | [Definition]
ChEBI: Zaltoprofen is an organic molecular entity. | [in vivo]
Zaltoprofen (5-20 mg/kg; a single p.o.) inhibits bradykinin-induced nociceptive responses in rats[2].
Zaltoprofen (3-30 mg/kg; a single p.o.) inhibits the acetic acid-induced writhing response of mice in a dose-dependent manner[2]. | Animal Model: | Eight-week-old male Wistar rats were injected Bradykinin every 15 min[2] | | Dosage: | 5, 10, 20 mg/kg | | Administration: | A single p.o. | | Result: | Inhibited bradykinin-induced nociceptive responses, with an ED50 of 9.7 mg/kg.
The duration of analgesic effect was 60-90 min. |
| [IC 50]
COX-2: 0.34 μM (IC50); COX-1: 1.3 μM (IC50) |
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