| Identification | Back Directory | [Name]
4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol | [CAS]
74812-63-8 | [Synonyms]
4-[(1R,2S)-2-amino-1-hydroxypropyl]benzene-1,2-diol | [Molecular Formula]
C9H13NO3 | [MOL File]
74812-63-8.mol | [Molecular Weight]
183.204 |
| Hazard Information | Back Directory | [Uses]
Nordefrin ((±)-Cobefri), a Norepinephrine (HY-13715) derivative, is a vasoconstrictor agent[1]. | [Definition]
ChEBI: Alpha-methylnoradrenaline is a catecholamine in which the 2-aminoethyl group is substituted with a hydroxy group at C-1 and a methyl group at C-2, with configurations 1R,2S. A metabolite of alpha-methyl-L-dopa, it is an alpha2-adrenergic agonist and acts as a topical nasal decongestant and vasoconstrictor, most often used in dentistry. It has a role as an alpha-adrenergic agonist, a vasoconstrictor agent and a nasal decongestant. | [References]
[1] V J Robertson, et al. Quantitative and qualitative analysis of the pressor effects of levonordefrin. J Cardiovasc Pharmacol. Sep-Oct 1984;6(5):929-35. DOI:10.1097/00005344-198409000-00029 |
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