| Identification | Back Directory | [Name]
CHF-5022 | [CAS]
749269-77-0 | [Synonyms]
CHF-5022
CHEMBL196246
UNII-JO8EVV007Q
Cyclopropanecarboxylic acid, 1-[2-fluoro-4'-(trifluoromethyl)[1,1'-biphenyl]-4-yl]- | [Molecular Formula]
C17H12F4O2 | [MOL File]
749269-77-0.mol | [Molecular Weight]
324.27 |
| Hazard Information | Back Directory | [Uses]
CHF5022 is an inhibitor of Aβ42 secretion (IC50=92 μM). CHF5022 retains a modest activity on Aβ40 at non-cytotoxic concentrations (?22.2±4.8% at 100 μM)[1]. | [in vivo]
After multiple oral administration, CHF5022 is absorbed dose-dependently, with a fair penetration of the brain (≈10%) of young Tg2575 mice[1]. | [References]
[1] Imbimbo BP, et al. In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents. Pharmacol Res. 2007 Apr;55(4):318-28. DOI:10.1016/j.phrs.2006.12.010 |
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