| Identification | Back Directory | [Name]
Methanesulfonamide, N-[5-(4,5-dihydro-1H-imidazol-2-yl)-5,6,7,8-tetrahydro-2-hydroxy-1-naphthalenyl]- | [CAS]
750531-54-5 | [Synonyms]
Methanesulfonamide, N-[5-(4,5-dihydro-1H-imidazol-2-yl)-5,6,7,8-tetrahydro-2-hydroxy-1-naphthalenyl]- | [Molecular Formula]
C14H19N3O3S | [MOL File]
750531-54-5.mol | [Molecular Weight]
309.38 |
| Hazard Information | Back Directory | [Description]
A61603 is an alpha-1A adrenergic receptor. | [Uses]
A-61603 free base is a potent adrenergic receptor agonist. A-61603 free base reduces carotid artery conductance in anesthetized pigs mediated by α1 and α2 adrenergic receptors (pEC50=7.25). A-61603 free base can be used as a probe to study adrenergic function[1][2]. | [Definition]
ChEBI: N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8-tetrahydronaphthalen-1-yl]methanesulfonamide is a member of tetralins. | [References]
[1] Knepper S M, et al. A-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A receptor subtype[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 274(1): 97-103. PMID:7616455
[2] Mehrotra S, et al. A61603‐Induced Contractions of the Porcine Meningeal Artery Are Mediated by α1‐and α2‐Adrenoceptors[J]. Basic & clinical pharmacology & toxicology, 2007, 100(4): 279-285. DOI:10.1111/j.1742-7843.2007.00050.x |
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