| Identification | Back Directory | [Name]
carbazomycin B | [CAS]
75139-38-7 | [Synonyms]
carbazomycin B
3-Methoxy-1,2-dimethyl-9H-carbazol-4-ol
4-Hydroxy-3-methoxy-1,2-dimethyl-9H-carbazole | [MDL Number]
MFCD01739920 | [MOL File]
75139-38-7.mol |
| Chemical Properties | Back Directory | [Occurrence]
An antibiotic alkaloid isolated from the cultures of an unclassified species of Streptomyces,
carbazomycin B has been isolated and characterized as the acetate which forms colourless
needles with m.p. 192-195°C. | [storage temp. ]
-20°C | [solubility ]
DMSO: Soluble
Methanol: Soluble | [form ]
A solid | [CAS DataBase Reference]
75139-38-7 |
| Hazard Information | Back Directory | [Uses]
Carbazomycin B is a bacterial metabolite and can be isolated from Streptomyces. Carbazomycin B is an antifungal and antibacterial agent. Carbazomycin B inhibits 5-lipoxygenase (5-LO) activity in extract from RBL-1 cell with the IC50 Of 1.5 μM[1]sup>[2]sup>[3]sup>[4]. | [storage]
-20°C | [References]
[1] Yamasaki K, Kaneda M, Watanabe K, et al. New antibiotics, carbazomycins A and B. III. Taxonomy and biosynthesis. J Antibiot (Tokyo). 1983;36(5):552-558. DOI:10.7164/antibiotics.36.552
[2] Sakano K, et al. New antibiotics, carbazomycins A and B. I. Fermentation, extraction, purification and physico-chemical and biological properties. J Antibiot (Tokyo). 1980;33(7):683-689. DOI:10.7164/antibiotics.33.683
[3] Naid T, et al. Carbazomycins C, D, E and F, minor components of the carbazomycin complex. J Antibiot (Tokyo). 1987;40(2):157-164. DOI:10.7164/antibiotics.40.157
[4] Hook DJ, et al. Identification of the inhibitory activity of carbazomycins B and C against 5-lipoxygenase, a new activity for these compounds. J Antibiot (Tokyo). 1990 Oct;43(10):1347-8. DOI:10.7164/antibiotics.43.1347 |
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