75144-12-6

Directory

75144-12-6 Structure

Identification	Back Directory
[Name] 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL
[CAS] 75144-12-6
[Synonyms] Antitrypanosomal agent 1 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL 1-(3,4-Dichlorophenyl)-3-dimethylamino-1-propanonehydrochloride 1-(3,4-dichlorophenyl)-3-(dimethylamino)propan-1-one hydrochloride
[Molecular Formula] C11H13Cl2NO.ClH
[MDL Number] MFCD01220371
[MOL File] 75144-12-6.mol
[Molecular Weight] 282.59

Chemical Properties	Back Directory
[Melting point ] 186 - 188°C
[storage temp. ] Inert atmosphere,2-8°C
[solubility ] DMSO (Slightly), Methanol (Slightly)
[form ] Solid
[color ] Off-White
[Water Solubility ] Water: 10 mg/mL (35.39 mM)

Safety Data	Back Directory
[Symbol(GHS) ] GHS07
[Signal word ] Warning
[Hazard statements ] H302-H315-H319-H335
[Precautionary statements ] P261-P305+P351+P338

Hazard Information	Back Directory
[Uses] Antitrypanosomal agent 1 is a potent and selective trypanothione reductase (TR) inhibitor with an IC50 of 3.3 μM. Antitrypanosomal agent 1 inhibits glutathione reductase (GR) (IC50=64.8 μM) and T. brucei (EC50=1 μM). Antitrypanosomal agent 1 has anti-trypanosomal activity[1].
[Biological Activity] Antitrypanosomal agent 1 is a potent and selective inhibitor of trypanothione reductase with IC50 of 3.3 μM. It inhibits glutathione reductase with IC50 of 64.8 μM; inhibits Trypanosoma brucei with EC50 of 1 μM. It has antitrypanosomal activity.
[in vitro] Antitrypanosomal agent 1 (compound 8a) has an selectivity for TR (GR IC50/TR IC50) of 20.
[target] IC50: 3.3 μM (trypanothione reductase) and 64.8 μM (glutathione reductase) EC50: 1 μM ( T. brucei )
[storage] Store at -20°C
[References] [1] Martyn DC, et al. High-throughput screening affords novel and selective trypanothione reductase inhibitors with anti-trypanosomal activity. Bioorg Med Chem Lett. 2007 Mar 1;17(5):1280-3. DOI:10.1016/j.bmcl.2006.12.016

Spectrum Detail	Back Directory
[Spectrum Detail] 1-(3,4-DICHLOROPHENYL)-3-DIMETHYLAMINO-1-PROPANONE HCL(75144-12-6)¹HNMR

75144-12-6 suppliers list

Company Name:	Wuxi Rejoys chemical Technology Co., Ltd.
Tel:	0510-86103381
Website:	www.rejoyschem.com

Company Name:	Hefei TNJ Chemical Industry Co.,Ltd.
Tel:	+86-0551-65418684 +8618949823763 , +8618949823763
Website:	www.tnjchem.com

Company Name:	Shanghai Acmec Biochemical Technology Co., Ltd.
Tel:	+86-18621343501; +undefined18621343501 , +undefined18621343501
Website:	http://www.acmec.com.cn/

Company Name:	SHANGHAI KEAN TECHNOLOGY CO., LTD.
Tel:	+8613817748580 , +8613817748580
Website:	www.kean-chem.com

Company Name:	Amadis Chemical Company Limited
Tel:	571-89925085
Website:	http://www.amadischem.com

Company Name:	Shanghai Synthfine Chemical Co.,Ltd
Tel:	15921303235
Website:	http://www.synthfine.com

Company Name:	Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel:	0-1502103-5486 18017383231
Website:	http://www.antaeus-e.com/

Company Name:	Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel:	028-81700200 18116577057
Website:	https://www.weikeqi-biotech.com/

Tags:75144-12-6 Related Product Information

6582-42-9

HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.

Login