| Identification | Back Directory | [Name]
7,8-DIHYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE | [CAS]
75187-63-2 | [Synonyms]
YN1
YN1 >=98% (HPLC)
4',7,8-Trihydroxy isoflavone
7,8-Dihydroxy-3-(4-hydroxy-pheny
7,8-DIHYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE
7,8-dihydroxy-3-(4-hydroxyphenyl)-4h-chroMen-4-one
7,8-DIHYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE 98%
4H-1-Benzopyran-4-one,7,8-dihydroxy-3-(4-hydroxyphenyl)- | [Molecular Formula]
C15H10O5 | [MDL Number]
MFCD00885567 | [MOL File]
75187-63-2.mol | [Molecular Weight]
270.24 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [color ]
white to beige | [Cosmetics Ingredients Functions]
SKIN CONDITIONING
BLEACHING
ANTIOXIDANT | [InChI]
1S/C15H10O5/c16-9-3-1-8(2-4-9)11-7-20-15-10(13(11)18)5-6-12(17)14(15)19/h1-7,16-17,19H | [InChIKey]
BMZFZTMWBCFKSS-UHFFFAOYSA-N | [SMILES]
[o]1c2c([c](c(c1)c3ccc(cc3)O)=O)ccc(c2O)O |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [HS Code ]
2932990090 | [Storage Class]
11 - Combustible Solids |
| Hazard Information | Back Directory | [Uses]
7,8-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one (7,8,4'-Trihydroxyisoflavone) is a product that can be isolated from [1]. | [Definition]
ChEBI: 8-Hydroxydaidzein is a member of isoflavones. | [Biochem/physiol Actions]
YN1 is a potent inhibitor of PFKFB3 (6-Phosphfructo-2-kinase/fructose-2,6-bisphosphatase: IC50 = 670 nM). PFKFB3 is over expressed in many cancers, and catalyzes the production of fructose-2,6-bisphosphate, which can potentiate PFK1 activity, enhancing glycolysis in tumor cells. YN1 inhibits glycolysis and proliferation in HeLa cells. |
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