| Identification | Back Directory | [Name]
7H,13H-6a,13a-Epidithio-1H,6H-pyrazino[1,2-a:4,5-a']diindole-6,13-dione, dodecahydro-1,4,8,11-tetrahydroxy-, (1S,4S,4aS,6aR,7aS,8S,11S,11aS,13aR,14aS)- | [CAS]
752236-16-1 | [Synonyms]
Rostratin A
7H,13H-6a,13a-Epidithio-1H,6H-pyrazino[1,2-a:4,5-a']diindole-6,13-dione, dodecahydro-1,4,8,11-tetrahydroxy-, (1S,4S,4aS,6aR,7aS,8S,11S,11aS,13aR,14aS)- | [Molecular Formula]
C18H24N2O6S2 | [MOL File]
752236-16-1.mol | [Molecular Weight]
428.52 |
| Hazard Information | Back Directory | [Uses]
Rostratin A is a cytotoxic disulfide found in the marine-derived fungus Exserohilum rostratum. Rostratin A shows in vitro cytotoxicity against human colon carcinoma (HCT-116) with an IC50 of 8.5 μg/mL[1]. | [IC 50]
Microbial Metabolite | [References]
[1] Tan RX, et al. Isolation and structure assignments of rostratins A-D, cytotoxic disulfides produced by the marine-derived fungus Exserohilum rostratum. J Nat Prod. 2004;67(8):1374-1382. DOI:10.1021/np049920b |
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