| Identification | Back Directory | [Name]
Pyrimidine,5-[(1E)-2-(3R)-3-pyrrolidinylethenyl]- | [CAS]
753015-44-0 | [Synonyms]
OC-02
Simpinicline
Pyrimidine,5-[(1E)-2-(3R)-3-pyrrolidinylethenyl]- | [Molecular Formula]
C10H13N3 | [MOL File]
753015-44-0.mol | [Molecular Weight]
175.23 |
| Hazard Information | Back Directory | [Uses]
Simpinicline (OC-02), a highly selective nicotinic acetylcholine receptor (nAChR) agonist, shows potent antiviral activity against the SARS-CoV-2 variants in cell culture with an IC50 of 0.04 μM[1]. | [References]
[1] Quik M, et al. α4β2 Nicotinic receptors play a role in the nAChR-mediated decline in L-dopa-induced dyskinesias in parkinsonian rats. Neuropharmacology. 2013 Aug;71:191-203. DOI:10.1016/j.neuropharm.2013.03.038 |
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