| Identification | Back Directory | [Name]
5-(1,3-benzodioxol-5-yl)-N-(2,4-dimethoxybenzyl)-1-methyl-1H-imidazol-2-amine | [CAS]
754998-88-4 | [Synonyms]
5-(1,3-benzodioxol-5-yl)-N-(2,4-dimethoxybenzyl)-1-methyl-1H-imidazol-2-amine
1H-Imidazol-2-amine, 5-(1,3-benzodioxol-5-yl)-N-[(2,4-dimethoxyphenyl)methyl]-1-methyl- | [Molecular Formula]
C20H21N3O4 | [MOL File]
754998-88-4.mol | [Molecular Weight]
367.4 |
| Hazard Information | Back Directory | [Uses]
TIC10g is a dual inhibitor for toll-like receptor 7 and 9 (TLR7 and TLR9), which inhibits TLR7 and TLR9 mediated TNF-α release in mouse macrophages (IC50 is 14.5 μM and 6.5 μM) and human B lymphocytes (IC50 is 7.69 μM and 11.5 μM). TIC10g inhibits the activation of NF-κB and MAPK, and exhibits anti-inflammatory activity against systemic lupus erythematosus and rheumatoid arthritis [1]. | [References]
[1] Haseeb M, et al., Discovery of Novel Small Molecule Dual Inhibitor Targeting Toll-Like Receptors 7 and 9. J Chem Inf Model. 2024 Jun 21. DOI:10.1021/acs.jcim.4c00578 |
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