| Identification | Back Directory | [Name]
H-Pro-Gly-Pro-OH | [CAS]
7561-51-5 | [Synonyms]
H-Pro-Gly-Pro-OH
L-Prolylglycyl-L-proline
L-Proline, L-prolylglycyl-
(2S)-1-[2-[[(2S)-pyrrolidine-2-carbonyl]amino]acetyl]pyrrolidine-2-carboxylicacid | [Molecular Formula]
C12H19N3O4 | [MOL File]
7561-51-5.mol | [Molecular Weight]
269.3 |
| Hazard Information | Back Directory | [Uses]
H-Pro-Gly-Pro-OH is a collagen-derived matrikine that has classically been described as a neutrophil chemoattractant. H-Pro-Gly-Pro-OH is perfectly positioned to focus neutrophils on the site required and direct a localized repair response. H-Pro-Gly-Pro-OH activates the transcription of neurotrophins and their receptor genes after cerebral ischemia[1][2]. | [in vivo]
H-Pro-Gly-Pro-OH (37.5 μg/kg; i.p.) activates the transcription of neurotrophins and their receptor genes after cerebral ischemia in rats[2]. | Animal Model: | 270-320 g, male Wistar rats (focal cerebral ischemia)[2] | | Dosage: | 37.5 μg/kg | | Administration: | I.p.; 15, 1 h, 4, 8, 24, 28, 32, 48, 52, and 56 h | | Result: | Enhanced the transcription of Bdnf and TrkC 3 h after pMCAO and Ngf, TrkB, TrkC, and TrkA 24 h after pMCAO. |
| [References]
[1] Patel DF, et al. The multifaceted roles of the matrikine Pro-Gly-Pro in pulmonary health and disease. Eur Respir Rev. 2018 Jun 27;27(148):180017. DOI:10.1183/16000617.0017-2018
[2] Dmitrieva VG, et al. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell Mol Neurobiol. 2010 Jan;30(1):71-9. DOI:10.1007/s10571-009-9432-0 |
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