| Identification | Back Directory | [Name]
Ancarolol | [CAS]
75748-50-4 | [Synonyms]
Ancarolol
N-[2-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]furan-2-carboxamide
N-[2-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]phenyl]-2-furancarboxamide
2-Furancarboxamide, N-[2-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]phenyl]- | [Molecular Formula]
C18H24N2O4 | [MDL Number]
MFCD00868358 | [MOL File]
75748-50-4.mol | [Molecular Weight]
332.39 |
| Chemical Properties | Back Directory | [Boiling point ]
433.7±45.0 °C(Predicted) | [density ]
1.183±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
12.26±0.70(Predicted) |
| Hazard Information | Back Directory | [Originator]
Ancarolol,ZYF Pharm Chemical | [Uses]
Ancarolol is a beta-adrenergic blocking agent. | [Manufacturing Process]
A mixture of 23 g of 2'-(2,3-epoxypropoxy)-furan-2-carboxylic acid anilide,
7.3 g of t-butylamine and 50 ml of isopropanol is boiled under reflux for 10
hours. On cooling, 2'-(2-hydroxy-3-t-butylaminopropoxy)-furan-2-carboxylic
acid anilide (ancarolol) crystallizes out from the solution. The
chromatographically pure base is obtained in the form of a white solid of
melting point 112°-113°C by recrystallization from ethyl acetate. The yield is
12 g. The colorless, crystalline base is dissolved in alcohol, alcoholic HCl is
added and the hydrochloride is induced to crystallize by adding ether
dropwise. After isolation, the salt is recrystallized again from ethanol. This
gives 10 g of the hydrochloride, melting point 189°-191°C. | [Therapeutic Function]
Beta-adrenergic blocker |
|
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