| Identification | Back Directory | [Name]
trans-clomifene citrate | [CAS]
7599-79-3 | [Synonyms]
Androxal
Enclomid
Unii-J303A6U9Y6
Enclomifene citrate
Clomiphene B citrate
Enclomiphene citrate
(E)-Clomiphene citrate
trans-clomifene citrate
trans-Clomiphene citrate
Enclomiphene Citrate /trans-Clomiphene
Triethylamine, 2-(p-(2-chloro-1,2-diphenylvinyl)phenoxy)-, citrate, (E)- | [EINECS(EC#)]
-0 | [Molecular Formula]
C32H36ClNO8 | [MDL Number]
MFCD00058322 | [MOL File]
7599-79-3.mol | [Molecular Weight]
598.083 |
| Chemical Properties | Back Directory | [Melting point ]
143-145°C | [storage temp. ]
Amber Vial, -20°C Freezer | [solubility ]
DMSO (Slightly), Ethyl Acetate (Slightly, Heated, Sonicated) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Light Sensitive | [InChIKey]
PYTMYKVIJXPNBD-BTKVJIOYSA-N |
| Hazard Information | Back Directory | [Uses]
trans-Clomiphene Citrate, stereoisomer of Clomiphene Citrate (C587025), a synthetic estrogen agonist-antagonist. Gonad-stimulating principle. | [Toxicology]
The effects of the cis and trans isomers of clomiphene citrate on the uterine hexokinase activity of immature ovariectomized rats were studied in long- and short-term experiments. At a dose level of 600 μg/kg, both trans-Clomiphene Citrate and cis-Clomiphene Citrate caused a similar increase in total uterine hexokinase activity observable in 18 hr. When enzyme activity was expressed per g of the uterus (specific activity), significant increases were noted 18 hr after a single injection of trans clomiphene or after 4 daily injections of either isomer. Treatment of these animals with 170-estradiol (5 μg/kg) caused an elevation of both the specific and total hexokinase activities within 18 hr[1].
| [in vivo]
Enclomiphene citrate (subcutaneous injection, 0.25 and 0.5 mg/animal, daily) inhibits spermatogenesis and decreases serum luteinizing hormone (LH) and testosterone levels in intact or castrated rats[5].
Enclomiphene citrate (oral adminstration, 0.03-3 mg/kg, daily for 90 days) reductes body weight to sham levels, and reduced serum cholesterol[6]. | Animal Model: | 21 days-old Charles River male rats[5] | | Dosage: | 0.25 and 0.5 mg/animal, daily for 24 days. | | Administration: | Subcutaneous injection | | Result: | Decreased LH and testosterone levels in the serum. |
| Animal Model: | OVX (ovariectomy) rat model[6] | | Dosage: | 0.03, 1, and 3 mg/kg, daily for 90 days. | | Administration: | Oral adminstration | | Result: | Reducted body weight to sham levels, and reduced serum cholesterol.
Showed dose-dependent effects on the proximal tibia with BMD and BMC approaching posttreatment Sham levels.
|
| [References]
[1] D L DiPietro, D A Goss, F J Sanders. “Effect of cis and trans isomers of clomiphene citrate on uterine hexokinase activity.” Endocrinology 84 6 (1969): 1404–8. |
|
|