| Identification | Back Directory | [Name]
1,2-DIAMINO-4,5-DIFLUOROBENZENE
| [CAS]
76179-40-3 | [Synonyms]
EA358
4,5-Difluoro-2-PhenylenediaMin
2-AMINO-4,5-DIFLUOROPHENYLAMINE
4,5-Difluoro-1,2-benzenediamine
4,5-Difluoro-o-phenylenediamine
4,5-Difluorobenzene-1,2-diamine
1,2-Diamino-4,5-difluorobenzene
4,5-Difluoro-2-PhenylenediaMine
4,5-Difluorophenylene-1,2-diamine
1,2-Benzenediamine, 4,5-difluoro-
4,5-Difluoro-1,2-phenylenediamine>
1,2-DIAMINO-4,5-DIFLUOROBENZENE ISO 9001：2015 REACH
4,5-Difluorophenylene-1,2-diamine, 1,2-Diamino-4,5-difluorobenzene | [EINECS(EC#)]
616-301-0 | [Molecular Formula]
C6H6F2N2 | [MDL Number]
MFCD00061131 | [MOL File]
76179-40-3.mol | [Molecular Weight]
144.12 |
| Chemical Properties | Back Directory | [Melting point ]
132 °C | [Boiling point ]
282.2±35.0 °C(Predicted) | [density ]
1.407±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
powder to crystal | [pka]
3.51±0.10(Predicted) | [color ]
White to Brown | [InChI]
InChI=1S/C6H6F2N2/c7-3-1-5(9)6(10)2-4(3)8/h1-2H,9-10H2 | [InChIKey]
PPWRHKISAQTCCG-UHFFFAOYSA-N | [SMILES]
C1(N)=CC(F)=C(F)C=C1N |
| Hazard Information | Back Directory | [Chemical Properties]
White powder | [Synthesis]
General procedure for the synthesis of 4,5-difluorophthalimide from 2-nitro-4,5-difluoroaniline: 4,5-difluoro-2-nitroaniline (10 g, 57 mmol) was co-suspended in methanol (150 mL) with 10% palladium carbon catalyst (2.0 g, 1.9 mmol). The reaction system was transferred to a hydrogenation unit and the catalytic hydrogenation reaction was carried out under 50 psi hydrogen pressure. After 3 hours of reaction, the catalyst was removed by filtration through a diatomaceous earth pad and the filtrate was concentrated under reduced pressure to give a solid product. The resulting solid was dried under vacuum at room temperature overnight to obtain white crystalline 4,5-difluorophthalimide (8.05 g, 98% yield). | [References]
[1] Journal of Medicinal Chemistry, 1993, vol. 36, # 3, p. 331 - 342
[2] Patent: US2005/43292, 2005, A1. Location in patent: Page/Page column 14
[3] Patent: EP2766359, 2016, B1. Location in patent: Paragraph 0755
[4] Journal of Medicinal Chemistry, 1997, vol. 40, # 5, p. 811 - 818
[5] Russian Journal of Organic Chemistry, 2001, vol. 37, # 4, p. 564 - 569 |
| Questions And Answer | Back Directory | [Application]
4,5-Difluorobenzene-1,2-diamine is an organic synthesis intermediate and a chemical and pharmaceutical intermediate, which can be used in the research and development of organic synthesis reactions in laboratories and in the research and development of chemical and pharmaceutical products. |
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