| Identification | Back Directory | [Name]
4-BROMO-A23187 | [CAS]
76455-48-6 | [Synonyms]
4-BR-A23187
4-BROMO-A23187
A23187, 4-BROMO
4-BROMOCALCIMYCIN
4-BROMO-ANTIBIOTIC
CALCIMYCIN, 4-BROMO
4-BROMOCALCIMYCIN A23187
4-BROMO-ANTIBIOTIC A23187
ANTIBIOTIC A-23187, 4-BROMO
4-BROMO-CALCIUM IONOPHORE A23187
4-Bromo-A23187, 4-Bromo-calcimycin
4-BROMO-CALCIUM IONOPHORE A23187FREE ACI D
A23187, 4-Bromo- - CAS 76455-48-6 - Calbiochem
4-BroMo A-23187, free acid [4-BroMo-calciuM Ionophore A23187], [Antibiotic A-23187, 4-BroMo]
6-broMo-5-(MethylaMino)-2-(((2R,3R,6S,8S,9R,11R)-3,9,11-triMethyl-8-((S)-1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl)-1,7-dioxaspiro[5.5]undecan-2-yl)Methyl)benzo[d]oxazole-4-carboxylic acid | [Molecular Formula]
C29H36BrN3O6 | [MDL Number]
MFCD00077667 | [MOL File]
76455-48-6.mol | [Molecular Weight]
602.52 |
| Chemical Properties | Back Directory | [Boiling point ]
735.4±60.0 °C(Predicted) | [density ]
1.43±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
ethanol: 20 mg/mL
| [form ]
powder
| [pka]
15.14±0.50(Predicted) | [color ]
yellow
| [InChIKey]
LDXQFZZGVTWFCF-FHYGWRBKSA-N | [SMILES]
CNc1c(Br)cc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(O)=O |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
20/21/22-36/37/38 | [Safety Statements ]
26-36/37/39-36/37 | [WGK Germany ]
3
| [HS Code ]
29419090 | [Storage Class]
13 - Non Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow powder | [Uses]
4-Bromo-A23187 is an ionophore that transports Zn2+ and Mn2+ with high selectivity over Ca2+. | [Uses]
4-Bromo-calcium Ionophore A23187 has been used for the activation of Ca2+/calmodulin kinase II (CaMKII) in HeLa cell line. It has also been used as a calcium mobilizer to investigate its effect on superoxide dismutase 1 (SOD1) aggregates in VSC 4.1 cells. | [Biochem/physiol Actions]
4-Bromo-calcium Ionophore A23187 is a modulator of apoptosis. It inhibits apoptosis in a concentration dependent manner in neutrophils which are aging in vitro and increases the intracellular Ca2+ levels. |
|
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Sigma-Aldrich
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021-61415566 800-8193336 |
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https://www.sigmaaldrich.cn |
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