| Identification | Back Directory | [Name]
1-AMINOPYRROLE | [CAS]
765-39-9 | [Synonyms]
LHTE
-1-amine
1-pyrrolamine
1-AMINOPYRROLE
pyrrol-1-amine
pyrrol-1-ylamine
1H-Pyrrol-1-amine
1-Aminopyrrole >
1-Amino-1H-pyrrole
1-AMINOPYRROLE（freebase) | [Molecular Formula]
C4H6N2 | [MDL Number]
MFCD00059931 | [MOL File]
765-39-9.mol | [Molecular Weight]
82.1 |
| Chemical Properties | Back Directory | [Melting point ]
77-78 °C | [Boiling point ]
174 | [density ]
1,06 g/cm3 | [refractive index ]
1.538 | [Fp ]
36 °C | [storage temp. ]
Refrigerator | [form ]
clear liquid | [pka]
-2.35±0.70(Predicted) | [color ]
Colorless to Orange to Green | [InChI]
InChI=1S/C4H6N2/c5-6-3-1-2-4-6/h1-4H,5H2 | [InChIKey]
YNZAFFFENDLJQG-UHFFFAOYSA-N | [SMILES]
N1(N)C=CC=C1 |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
10-34-22 | [Safety Statements ]
16-26-36-45-36/37/39 | [RIDADR ]
2734 | [WGK Germany ]
WGK 3 | [HS Code ]
2933.99.9701 | [HazardClass ]
8 | [PackingGroup ]
Ⅲ | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Flam. Liq. 3
Skin Corr. 1B |
| Hazard Information | Back Directory | [Uses]
1H-Pyrrol-1-amine is used in preparation of reproducible and high-temp. thermosetting flame-retardant resin. | [Synthesis]
Step 2: Synthesis of 1H-pyrrol-1-amine
To a solution of 2-(1H-pyrrol-1-yl)isoindoline-1,3-dione (3.5 g, 0.016 mmol) in methanol (35 mL) was added hydrazine monohydrate (1 mL, 0.021 mmol). The reaction mixture was heated to 65 °C and kept for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and filtered. The collected solid was washed with methanol, the filtrate was combined and concentrated to give a light yellow solid. The solid was ground with ether and then the organic solution was concentrated to give 1-aminopyrrole as a brown oil (1 g, 74% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 5.84 (t, J = 2.0 Hz, 2H), 5.86 (d, exchangeable with D2O, 2H), 6.62 (t, J = 2.0 Hz, 2H). | [References]
[1] Journal of Organic Chemistry, 2007, vol. 72, # 24, p. 9395 - 9397
[2] Patent: WO2012/125887, 2012, A1. Location in patent: Page/Page column 63
[3] Patent: WO2012/125886, 2012, A1. Location in patent: Page/Page column 73; 74
[4] Journal of Organic Chemistry, 1997, vol. 62, # 9, p. 2894 - 2906
[5] Patent: US2011/183983, 2011, A1. Location in patent: Page/Page column 24 |
|
|