| Identification | Back Directory | [Name]
BAM-22P | [CAS]
76622-26-9 | [Synonyms]
BAM22
AP1B1
ADTB1
AP105A
BAM-22P
Peptide E(1-22)
YGGFMRRVGRPEWWMDYQKRYG
BOVINE ADRENAL MEDULLA-22P
BOVINE ADRENAL MEDULLA DOCOSAPEPTIDE
TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU-TRP-TRP-MET-ASP-TYR-GLN-LYS-ARG-TYR-GLY
H-TYR-GLY-GLY-PHE-MET-ARG-ARG-VAL-GLY-ARG-PRO-GLU-TRP-TRP-MET-ASP-TYR-GLN-LYS-ARG-TYR-GLY-OH
BAM-22P H-Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH
L-Tyr-Gly-Gly-L-Phe-L-Met-L-Arg-L-Arg-L-Val-Gly-L-Arg-L-Pro-L-Glu-L-Trp-L-Trp-L-Met-L-Asp-L-Tyr-L-Gln-L-Lys-L-Arg-L-Tyr-Gly-OH | [Molecular Formula]
C130H184N38O31S2 | [MDL Number]
MFCD00076690 | [MOL File]
76622-26-9.mol | [Molecular Weight]
2839.22 |
| Chemical Properties | Back Directory | [density ]
1.50±0.1 g/cm3(Predicted) | [RTECS ]
SC6200500 | [storage temp. ]
-15°C | [solubility ]
Soluble to 1 mg/ml in H2O | [form ]
Lyophilized solid | [Water Solubility ]
Soluble to 1 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
BAM-22P, a highly potent opioid peptide, is a potent opioid agonist. | [Biological Activity]
bovine adrenal medulla 22 peptide (bam22p) is a peptide with 22 amino acids which is one of the cleavage products of proenkephalin a, the precursor of leu- and met-enkephalin, in the adrenal medulla, with very potent opiate activity. | [in vitro]
in the guinea-pig ileum assay, bam-22p has been shown to have typical and extraordinarily potent opioid activities antagonized by naloxone. the potency of bam-22p is 26 times that of met-enkephalin and 22 times that of b hendorphin. ic50 value of bam-22p in this tissue, 1.3 nm, makes it the most potent met-enkephalin relatives that discoveried so far. [1]. | [in vivo]
intrathecal (i.t.) administration of bam22 decreased nocifensive behavior scores, which measured as the sum of flinching and lifting/licking, in the first and second phases of the formalin test. such decrease was partially attenuated by systemic injection of naloxone. [2]. | [target]
| [IC 50]
1.3 nm for opiate activity | [storage]
Desiccate at -20°C | [References]
[1] mizuno k, minamino n, kangawa k, matsuo h. a new family of endogenous "big" met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (bam-22p) and eicosapeptide (bam-20p) with very potent opiate activity. biochem biophys res commun. 1980 dec 31;97(4):1283-90.
[2] hong y, dai p, jiang j, zeng x. dual effects of intrathecal bam22 on nociceptive responses in acute and persistent pain--potential function of a novel receptor. br j pharmacol. 2004 feb;141(3):423-30. |
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