| Identification | Back Directory | [Name]
(R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID | [CAS]
766536-21-4 | [Synonyms]
PF-356231
PF 00356231
(R)-3-PHENYL-3-([4-(4-PYRIDIN-4-YL-PHENYL)-THIOPHENE-2-CARBONYL]-AMINO)-PROPIONIC ACID
BENZENEPROPANOIC ACID, B-[[[4-[4-(4-PYRIDINYL)PHENYL]-2-THIENYL]CARBONYL]AMINO]-, (BR)-
Benzenepropanoic acid, β-[[[4-[4-(4-pyridinyl)phenyl]-2-thienyl]carbonyl]amino]-, (βR)- | [Molecular Formula]
C25H20N2O3S | [MDL Number]
MFCD10565940 | [MOL File]
766536-21-4.mol | [Molecular Weight]
428.5 |
| Chemical Properties | Back Directory | [Boiling point ]
673.553±55.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.290±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Yellow solid. | [pka]
4.153±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
PF-00356231 hydrochloride is a specific, non-peptidic, non-zinc chelating ligand and inhibitor of matrix metalloproteinase MMP-12 (IC50=1.4 μM). PF-00356231 hydrochloride binds to MMP-12 and forms PF-00356231/MMP-12 complex. PF-00356231 hydrochloride shows potency against MMP-13, MMP-8, MMP-9, MMP-3 with IC50s of 0.00065, 1.7, 0.98, 0.39 μM, respectively[1]. | [References]
[1] Morales R, et al. Crystal structures of novel non-peptidic, non-zinc chelating inhibitors bound to MMP-12. J Mol Biol. 2004 Aug 20;341(4):1063-76. DOI:10.1016/j.jmb.2004.06.039 |
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