| Identification | Back Directory | [Name]
Azathramycin | [CAS]
76801-85-9 | [Synonyms]
Desmethyl
Azathramycin
Azithromycin A
Azaerthromycin A
Azaerythromycin A
Azithromycin Amine
Desmethylazythromicin
DESMETHYL AZITHROMYCIN
Azithromycin EP Impurity A
AzithroMycin InterMediates
9-DEOXO-9A-AZA-9A-HEMOERYTHROMYCIN
Azathramycin (Desmethyl Azithromycin)
9-Deoxo-9a-aza-9a-homo Erythromycin A
10-dihydro-10-deoxo-11-azaerythromycin A
6-DeMethylazithroMycin (AzaerythroMycin A)
10-Dihydro-10-deoxo-11-azaethrythroMycin A
9-Deoxo-9a-aza-9a-homo Erythromycin A
Desmethyl Azithromycin
AZAERYTHROMYCIN A (100 MG) (9-DEOXO-9A-AZA-9A-HOMOERYTHROMYCIN A)
1-Oxa-6-azacyclopentadecan-15-one,13-[(2,6-dideoxy-3-C-Methyl-3-O-Methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,8,10,12,14-hexaMethyl-11-[[3,4,6-trideoxy-3-(diMethylaMino)-b-D-xylo-hexopyranosyl]oxy]-,(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R | [EINECS(EC#)]
616-385-9 | [Molecular Formula]
C37H70N2O12 | [MDL Number]
MFCD09038719 | [MOL File]
76801-85-9.mol | [Molecular Weight]
734.962 |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
126-136°C | [Boiling point ]
815.2±65.0 °C(Predicted) | [density ]
1.18 | [storage temp. ]
-20?C Freezer | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
neat | [pka]
13.29±0.70(Predicted) | [color ]
White to Off-White | [Stability:]
Hygroscopic | [InChIKey]
HRKNNHYKWGYTEN-HOQMJRDDSA-N | [LogP]
3.11 | [CAS DataBase Reference]
76801-85-9 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Novel intermediate of Azithromycin that acts as antibiotic | [Synthesis]
Example-2; [93] [94] Preparation of 9-deoxy-9a-azo-9a-homoerythromycin A; Acetic acid was added dropwise to a methanolic (700 mL) suspension of 6,9-imino ether (II) (70.0 g), and the pH was adjusted to 5-6. Subsequently, an aqueous solution of PtO2 (7.0 g) was added to the above mixture and the reaction was carried out under a hydrogen pressure of 8-9 kg/cm2 and a temperature of 40-45°C for 4-5 hours for the hydrogenation reduction reaction. After completion of the reaction, the reaction mixture was filtered through Hyflo Super Cel and the filter cake was washed with methanol. The filtrates were combined and the methanol was removed by distillation under reduced pressure. To the residue, deionized water (700 mL) was added and the pH was adjusted to 11-12 with aqueous sodium hydroxide.The precipitated solid was filtered, drained, and dried in an oven to afford 9-deoxy-9a-azo-9a- homoerythromycin A(III) (55.0 g) in 85% yield. | [storage]
Store at -20°C | [References]
[1] Patent: WO2009/156938, 2009, A2. Location in patent: Page/Page column 8
[2] Patent: CN106632543, 2017, A. Location in patent: Paragraph 0003; 0025-0026
[3] Organic and Biomolecular Chemistry, 2008, vol. 6, # 22, p. 4120 - 4124
[4] Patent: CN106478541, 2017, A. Location in patent: Paragraph 0022; 0047 |
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