768350-54-5

367-24-8

162364-72-9

768350-54-5

General procedure for the synthesis of 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine from 4-bromo-2-fluoroaniline and 7-benzyloxy-4-chloro-6-methoxyquinazoline: 6.5 M hydrogen chloride (2.54 mL) was added to a 2-propanol (160 mL) solution containing 4-bromo-2-fluoroaniline (4.51 g, 15.0 mmol) and 7-benzyloxy-4- chloro-6-methoxyquinazoline (2.40 g, 16.5 mmol) in a solution of 2-propanol (160 mL). Subsequently, the reaction mixture was heated to reflux and kept for 2 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the precipitated solid product was collected by filtration. The solid was washed sequentially with 2-propanol and ether and finally dried under vacuum overnight to afford the target compound 7-(benzyloxy)-N-(4-bromo-2-fluorophenyl)-6-methoxyquinazolin-4-amine (7.9 g, 94% yield) as a white solid.