| Hazard Information | Back Directory | [Description]
LY52 is an inhibitor of matrix metalloproteinase-2. It acts by suppressing tumor invasion and metastasis. | [Uses]
LY52 is an MMP-2 and MMP-9 inhibitor. LY52 can significantly block the proteolytic activity of gelatinases, reducing the expression of MMP-2 and MMP-9 in SKOV3 cells, thereby inhibiting cell invasion. LY52 can also suppress the pulmonary metastasis of Lewis lung carcinoma cells in mice. LY52 may be used in cancer research[1]. | [IC 50]
MMP-9; MMP-2 | [References]
[1] Qu X, et al. Caffeoyl pyrrolidine derivative LY52 inhibits tumor invasion and metastasis via suppression of matrix metalloproteinase activity. Anticancer Res. 2006 Sep-Oct;26(5A):3573-8. PMID:17094485 |
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