| Identification | Back Directory | [Name]
APROBARBITAL METHANOL SOLUTION | [CAS]
77-02-1 | [Synonyms]
Numal
Isonal
Aprozal
Allonal
Alurate
Allional
NSC120769
Aprobarbita
Allypropymal
Allylpropymal
Aprobarbitone
isonal(swedish)
Allopropylbarbital
alurateelixirverdum
Alurate Elixir Verdum
Propallylonal M (des-Br)
Allylisopropylmalonylurea
allylisopropylbarbituricacid
isopropylallylbarbituricacid
Isopropylallylbarbituric acid
allyisopropyl-barbituric acid
Allylisopropylbarbituric acid
Aprobarbital Solution, 100ppm
5-Allyl-5-isopropylbarbiturate
APROBARBITAL METHANOL SOLUTION
5-allyl-5-isopropyl-barbituricaci
5-allyl-5-isopropylbarbituricacid
5-isopropyl-5-allylbarbituricacid
5-Isopropyl-5-allylbarbituric acid
5-Allyl-5-isopropylbarbituric acid
5-Ally-5-isopropyl barbituric acid
Aprobarbital (base and/or unspecified salts)
Aprobarbital CIII (200 mg) (AS) DISCONTINUED
5-Allyl-5-isopropyl-2,4,6(1H,3H,5H)-pyrimidinetrione
6(1h,3h,5h)-pyrimidinetrione,5-(1-methylethyl)-5-(2-propenyl)-4
5-(1-methylethyl)-5-(2-propenyl)-2,4,6(1h,3h,5h)-pyrimidinetrione
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylethyl)-5-(2-propenyl)-
5-(1-Methylethyl)-5-(2-propen-1-yl)-2,4,6(1H,3H,5H)-pyriMidinetrione
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylethyl)-5-(2-propen-1-yl)- | [EINECS(EC#)]
200-997-4 | [Molecular Formula]
C10H14N2O3 | [MOL File]
77-02-1.mol | [Molecular Weight]
210.23 |
| Chemical Properties | Back Directory | [Melting point ]
140-141.5° | [Boiling point ]
349.75°C (rough estimate) | [density ]
1.2056 (rough estimate) | [refractive index ]
1.5000 (estimate) | [storage temp. ]
2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
7.81±0.10(Predicted) | [color ]
White to Off-White | [Water Solubility ]
4.121g/L(25 ºC) | [Major Application]
forensics and toxicology | [InChI]
1S/C10H14N2O3/c1-4-5-10(6(2)3)7(13)11-9(15)12-8(10)14/h4,6H,1,5H2,2-3H3,(H2,11,12,13,14,15) | [InChIKey]
UORJNBVJVRLXMQ-UHFFFAOYSA-N | [SMILES]
O=C1C(C(C)C)(CC=C)C(NC(N1)=O)=O |
| Safety Data | Back Directory | [Hazard Codes ]
F,T | [Risk Statements ]
11-23/25-36/38 | [Safety Statements ]
16-24-45 | [WGK Germany ]
WGK 2 | [Storage Class]
3 - Flammable liquids | [Hazard Classifications]
Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Flam. Liq. 2
STOT SE 1 | [Hazardous Substances Data]
77-02-1(Hazardous Substances Data) | [Toxicity]
LD50 i.p. in mice: 200 mg/kg (Frey) | [DEA Controlled Substances]
CSCN: 2100
CSA SCH: Schedule III
NARC: No |
| Hazard Information | Back Directory | [Originator]
Alurate,Roche | [Uses]
Controlled substance (depressant). Sedative, hypnotic. | [Definition]
ChEBI: A member of the class of barbiturates that is pyrimidine-2,4,6(1H,3H,5H)-trione substituted by an isopropyl and a prop-1-en-3-yl group at position 5. | [Manufacturing Process]
170 parts of isopropylbarbituric acid are mixed with 500 parts of water and
dissolved by adding 135 parts of a 30 percent of the solution of sodium
hydroxide. To this solution are added 130 parts of 130 parts of allylbromide.
An emulsion obtained is stirred at an inner temperature of about 25°C. The
reaction is at first accompanied by a slight development of heat. After 12
hours the reaction is brought to a close. When cooled down the
isopropylallylbarbituric acid is drawn off. The yield is more than 80 percent of
the theoretically calculated quantity. By crystallization from diluted alcohol the
pure isopropylallylbarbituric acid is obtained in colorless crystals of the melting
point 137-138°C. | [Therapeutic Function]
Sedative, Hypnotic | [World Health Organization (WHO)]
Aprobarbital is an intermediate-acting barbiturate. See WHO
comment for barbiturates. |
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