| Identification | Back Directory | [Name]
O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodo L-tyrosine | [CAS]
77074-49-8 | [Synonyms]
Thyroxine sulfate
L-Thyroxine sulfate
Thyroxine 4'-O-Sulfate
L-Thyroxine sulfate salt
Thyroxine Hydrogen Sulfate
O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodo L-tyrosine
L-Tyrosine, O-[3,5-diiodo-4-(sulfooxy)phenyl]-3,5-diiodo- | [Molecular Formula]
C15H11I4NO7S | [MDL Number]
MFCD24386428 | [MOL File]
77074-49-8.mol | [Molecular Weight]
856.93 |
| Chemical Properties | Back Directory | [density ]
2.658±0.06 g/cm3(Predicted) | [storage temp. ]
Store at 4°C | [solubility ]
DMSO : ≥ 31 mg/mL (36.18 mM) | [form ]
Solid | [pka]
-4.80±0.18(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Thyroxine 4-O-Sulfate is a metabolite and sulfoconjugated derivative of Thyroxine (T425600). | [Definition]
ChEBI: An iodothyronine having iodo substituents in the 3-, 3'-, 5- and 5'-positions and a sulfate group attached to the phenol function. | [in vivo]
Significant amounts of thyroxine sulfate (T4S) in fetal sheep serum, meconium, bile, and amniotic and allantoic fluids are observed. T4S concentration in amniotic fluid from women at 18-19 weeks of gestation (25.5 ng/dL) is higher than that at 14-15 weeks of gestation (14.3 ng/dL). A significant rise in serum T4S is detected in hyperthyroid patients 1 day after ingestion of 1 g of ipodate[1]. Thyroxine undergoes significant sulfation in rats, and biliary excretion of T4S is enhanced if its type I deiodination is inhibited[2]. Serum T4S levels are clearly elevated compared with healthy references, and the decreased deiodination by liver D1 during critical illness appears to play a role in this increase in serum T4S levels[3]. | [IC 50]
Human Endogenous Metabolite | [storage]
Store at 4°C |
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