| Identification | Back Directory | [Name]
Benzenesulfonamide, 4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)-, hydrochloride (1:1) | [CAS]
77113-78-1 | [Synonyms]
hCAIX-IN-14
Benzenesulfonamide, 4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)-, hydrochloride (1:1) | [Molecular Formula]
C11H17ClN6O2S | [MOL File]
77113-78-1.mol | [Molecular Weight]
332.81 |
| Hazard Information | Back Directory | [Uses]
hCAIX-IN-14 (compound 5a) is a potent inhibitor of human CA IX with a Ki value of 134.8 nM[1]. | [IC 50]
hCA IX: 134.8 nM (Ki) | [References]
[1] Zain-Alabdeen AI, et al. Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX. Sci Rep. 2022 Oct 6;12(1):16756. DOI:10.1038/s41598-022-21024-7 |
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